Synthesis
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3-Chloro-4-fluoronitrobenzene

Synthesis
Product Name
3-Chloro-4-fluoronitrobenzene
CAS No.
350-30-1
Chemical Name
3-Chloro-4-fluoronitrobenzene
Synonyms
2-CHLORO-1-FLUORO-4-NITROBENZENE;3-Chloro-4-fluoronit;Gefitinib Impurity 92;3-chloro-4-fluorobenzene;3-CHLORO-4-FLUORONITROANILINE;4-FLUORO-3-CHLORONITROBENZENE;3-CHLORO-4-FLUORONITROBENZENE;3-chioro-4-fluoronitrobenzene;1-CHLORO-2-FLUORO-5-NITROBENZENE;2-chloro-1-fluoro-4-nitro-benzen
CBNumber
CB9743847
Molecular Formula
C6H3ClFNO2
Formula Weight
175.54
MOL File
350-30-1.mol
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3-Chloro-4-fluoronitrobenzene Property

Melting point:
40-42 °C(lit.)
Boiling point:
227-232°C
Density 
1.61
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Light yellow to Green
BRN 
1944997
CAS DataBase Reference
350-30-1(CAS DataBase Reference)
NIST Chemistry Reference
3-Chloro-4-fluoronitrobenzene(350-30-1)
EPA Substance Registry System
3-Chloro-4-fluoronitrobenzene (350-30-1)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41-36/37/38-20/21/22
Safety Statements 
26-39-36/37/39
RIDADR 
2811
WGK Germany 
3
RTECS 
CZ0720000
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29049090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
233234
Product name
2-Chloro-1-fluoro-4-nitrobenzene
Purity
98%
Packaging
25g
Price
$204
Updated
2024/03/01
TCI Chemical
Product number
C1041
Product name
3-Chloro-4-fluoronitrobenzene
Purity
>95.0%(GC)
Packaging
25g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
C1041
Product name
3-Chloro-4-fluoronitrobenzene
Purity
>95.0%(GC)
Packaging
250g
Price
$96
Updated
2024/03/01
Alfa Aesar
Product number
A16183
Product name
2-Chloro-1-fluoro-4-nitrobenzene, 98%
Packaging
50g
Price
$69.9
Updated
2021/12/16
Alfa Aesar
Product number
A16183
Product name
2-Chloro-1-fluoro-4-nitrobenzene, 98%
Packaging
25g
Price
$46.5
Updated
2021/12/16
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3-Chloro-4-fluoronitrobenzene Chemical Properties,Usage,Production

Synthesis

In certain instances, when both chloro and nitro may act as a leaving group, a surprising selectivity of one over the other is observed, for example chloro-2,5- dinitrobenzene was converted to 4-fluoro-3-chloronitrobenzene.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-1-fluoro-4-nitrobenzene is an intermediate used in synthesis of benzoimidolones on Ameba resin and methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate.

Uses

2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:

  • benzoimidolones on Ameba resin
  • methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Synthetic Communications, 21, p. 505, 1991 DOI: 10.1080/00397919108016776

General Description

2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)6 and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.

3-Chloro-4-fluoronitrobenzene Preparation Products And Raw materials

Raw materials

4-Fluoronitrobenzene Fluorobenzene

Preparation Products

Norfloxacin 1,3-Dichloro-4-fluorobenzene
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3-Chloro-4-fluoronitrobenzene Suppliers

Americas 1 Belgium 2 Canada 3 China 278 Europe 4 France 2 Germany 4 India 17 Italy 1 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 15 United States 49 Global 387
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View Lastest Price from 3-Chloro-4-fluoronitrobenzene manufacturers

Henan Fengda Chemical Co., Ltd
Product
3-Chloro-4-fluoronitrobenzene 350-30-1
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Baoji Guokang Healthchem co.,ltd
Product
3-Chloro-4-fluoronitrobenzene 350-30-1
Price
US $79.00/KG
Min. Order
1KG
Purity
99
Supply Ability
10T
Release date
2021-06-07
Honest Joy Holdings Limited
Product
3-Chloro-4-fluoronitrobenzene 350-30-1
Price
US $0.00/KG
Min. Order
1KG
Purity
97.4%
Supply Ability
100 tons
Release date
2022-02-18

350-30-1, 3-Chloro-4-fluoronitrobenzeneRelated Search:

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