TETRAHYDRO-2H-PYRAN-3-OL

Product Name: TETRAHYDRO-2H-PYRAN-3-OL
CAS No.: 19752-84-2
Chemical Name: TETRAHYDRO-2H-PYRAN-3-OL
Synonyms: oxan-3-ol;DK653;3-Hydroxy-2H-pyran;TETRAHYDRO-PYRAN-3-OL;Pyran-3-ol, tetrahydro-;TETRAHYDRO-2H-PYRAN-3-OL;3-Hydroxytetrahydropyran;(s)-Tetrahydro-pyran-3-ol;3-Hydroxytetrahydropyrane;2H-Pyran-3-ol, tetrahydro-
CBNumber: CB9748231
Molecular Formula: C5H10O2
Formula Weight: 102.13
MOL File: 19752-84-2.mol

More

Less

TETRAHYDRO-2H-PYRAN-3-OL Property

Boiling point:: 88 °C(Press: 18 Torr)
Density: 1.080±0.06 g/cm3(Predicted)
refractive index: 1.457
storage temp.: 2-8°C
pka: 14.49±0.20(Predicted)
form: liquid
color: Colourless to light yellow
InChI: InChI=1S/C5H10O2/c6-5-2-1-3-7-4-5/h5-6H,1-4H2
InChIKey: BHDLTOUYJMTTTM-UHFFFAOYSA-N
SMILES: C1OCCCC1O

More

Less

Safety

HS Code: 2932990090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TRC

Product number: T294700
Product name: Tetrahydropyran-3-ol
Packaging: 100mg
Price: $165
Updated: 2021/12/16

Matrix Scientific

Product number: 073867
Product name: Tetrahydro-2H-pyran-3-ol
Purity: 95+%
Packaging: 1g
Price: $125
Updated: 2021/12/16

Ark Pharm

Product number: P000067430
Product name: Tetrahydro-2H-pyran-3-ol
Purity: 97%
Packaging: 10g
Price: $188
Updated: 2021/12/16

Matrix Scientific

Product number: 073867
Product name: Tetrahydro-2H-pyran-3-ol
Purity: 95+%
Packaging: 5g
Price: $400
Updated: 2021/12/16

Apolloscientific

Product number: OR46583
Product name: 3-Hydroxy-2H-pyran
Packaging: 1g
Price: $51
Updated: 2021/12/16

More

Less

TETRAHYDRO-2H-PYRAN-3-OL Chemical Properties,Usage,Production

Uses

Tetrahydro-2H-pyran-3-ol is a 3-substituted tetrahydropyran used in the preparation of herbicides as well as pyrazolothiazole compounds as CRF1 (corticotropin-releasing factor type 1) receptor antagonists.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 2282, 1970 DOI: 10.1021/jo00832a038

Synthesis

110-87-2

19752-84-2

Under nitrogen protection, 3,4-dihydro-2H-pyran (840 g, 10 mol) was dissolved in 4000 g of anhydrous tetrahydrofuran and cooled to 0 °C. A 1M borane tetrahydrofuran complex solution (6000 mL, 6 mol) was added dropwise at 0 °C and stirring was maintained. Subsequently, the reaction mixture was slowly cooled from room temperature to 0 °C over a period of 2 h and 3000 g of 20% NaOH aqueous solution was added dropwise. After the dropwise addition, hydrogen peroxide (1700 g, 15 mol) was added dropwise, the reaction temperature was controlled at 48 °C and stirred at room temperature for 9 hours. Upon completion of the reaction, saturated Na2S2O3 solution was added to quench the hydrogen peroxide, followed by concentration. The aqueous phase was extracted three times with 2000 g of dichloromethane, and the organic phases were combined, dried and concentrated. Finally, distillation was carried out under reduced pressure by pumping and the fractions were collected at an oil bath temperature of 140 °C and a fraction temperature of 100 °C to give 550 g of a colorless oily liquid with a purity of 98% and a yield of 52.8%.

References

[1] Journal of the Chemical Society, Chemical Communications, 1987, p. 1857 - 1859
[2] Patent: CN107382928, 2017, A. Location in patent: Paragraph 0007; 0010; 0013
[3] Patent: CN104650049, 2018, B. Location in patent: Paragraph 0599; 0600
[4] Canadian Journal of Chemistry, 1983, vol. 61, p. 1924 - 1932
[5] Liebigs Annalen der Chemie, 1983, # 11, p. 1950 - 1958

TETRAHYDRO-2H-PYRAN-3-OL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

TETRAHYDRO-2H-PYRAN-3-OL Suppliers

Canada 1 China 154 Europe 1 India 5 United Kingdom 1 United States 13 Global 175

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Biofine International Inc.

Tel: --
Fax: --
Email: sales@biofineintl.com
Country: United States
ProdList: 653
Advantage: 38

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6730
Advantage: 64

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

J & W PharmLab, LLC

Tel: --
Fax: --
Email: services@jwpharmlab.com
Country: United States
ProdList: 4156
Advantage: 63

More

Less

View Lastest Price from TETRAHYDRO-2H-PYRAN-3-OL manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tetrahydropyran-3-ol 19752-84-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Career Henan Chemical Co

Product: TETRAHYDRO-PYRAN-3-OL 19752-84-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg
Release date: 2018-08-16

19752-84-2, TETRAHYDRO-2H-PYRAN-3-OLRelated Search:

TETRAHYDRO-PYRAN-3-CARBALDEHYDE TETRAHYDRO-2H-PYRAN-3-CARBOXYLIC ACID 2H-PYRAN-3(4H)-ONE, DIHYDRO- Tetrahydropyran-4-boronic acid pinacol ester Tetrahydro-2H-pyran-4-carbonyl chloride Tetrahydro-4-pyranol Methyl tetrahydropyran-4-carboxylate Tetrahydro-2H-pyran-4-carboxylic acid TETRAHYDRO-3-FUROIC ACID TETRAHYDROPYRAN-4-BORONIC ACID 4-Amidinotetrahydro-2H-pyran hydrochloride Methyl tetrahydro-3-furoate 2-Furamide,tetrahydro-(6CI,7CI) Tetrahydro-2-furancarboxaldehyde TETRAHYDRO-FURAN-3-CARBONYL CHLORIDE TETRAHYDROFURAN-3-BORONIC ACID PINACOL ESTER TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER Tetrahydropyran-4-SulfonylChloride

TETRAHYDRO-PYRAN-3-OL

3-Hydroxytetrahydropyran

TETRAHYDRO-2H-PYRAN-3-OL

3-Hydroxy-2H-pyran

2H-Pyran-3-ol, tetrahydro-

Pyran-3-ol, tetrahydro-

Tetrahydro-2H-Pyran-3-Ol(WX642095)

3-Hydroxytetrahydropyrane

oxan-3-ol

(s)-Tetrahydro-pyran-3-ol

(+)-3-Hydroxytetrahydro-2H-pyran

DK653

19752-84-2

Aliphatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals