ChemicalBook > CAS DataBase List > CLOSTRIPAIN
CLOSTRIPAIN
- Product Name
- CLOSTRIPAIN
- CAS No.
- 9028-00-6
- Chemical Name
- CLOSTRIPAIN
- Synonyms
- PROTEINASE;CLOSTRIPAIN;EC 3.4.22.8;IUB: 3.4.22.8;E.C. 3.4.4.20;alpha-Clostripain;ENDOPROTEINASE-ARG-C;CLOSTRIDIOPEPTIDASE B;clostripain from clost. histolyticum;Clostridium histolyticum proteinase B
- CBNumber
- CB9768318
- Formula Weight
- 0
- MOL File
- Mol file
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CLOSTRIPAIN Property
- storage temp.
- 2-8°C
- form
- lyophilized powder
- color
- White to off-white
- Water Solubility
- Soluble in water
- Specific Activity
- ≥20units/mg solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C0888
- Product name
- Clostripain from Clostridium histolyticum
- Purity
- ≥20?units/mgsolid
- Packaging
- 250units
- Price
- $848
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J61362
- Product name
- Clostripain, Clostridium histolyticum
- Packaging
- 1mg
- Price
- $66
- Updated
- 2023/06/20
Alfa Aesar
- Product number
- J61362
- Product name
- Clostripain, Clostridium histolyticum
- Packaging
- 10mg
- Price
- $385
- Updated
- 2023/06/20
Usbiological
- Product number
- C5860
- Product name
- Clostripain
- Packaging
- 5mg
- Price
- $418
- Updated
- 2021/12/16
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CLOSTRIPAIN Chemical Properties,Usage,Production
Uses
A protease that cleaves proteins on the carboxyl bond of arginine
Uses
Clostripain from Clostridium histolyticum has been used as a proteolytic enzyme in perfusate to detect its effect on tube hematocrit. It has also been used in limited proteolysis of DNA polymerase (gp43) of phage T4 (RB69 gp43).
Biochem/physiol Actions
Clostripain from Clostridium histolyticum is composed of two polypeptide chains, with molecular masses of 41.7 kDa and 15.4 kDa. Clostripain has a highly restricted substrate specificity for Arg-Xaa peptide bonds. Therefore, clostripain has been explored as a potential enzyme for protein sequencing purposes. It has also been studied as a catalyst for condensation of pharmaceutically important peptides containing Arg-Pro bonds.
Purification Methods
Clostripain is isolated from Clostridium histolyticum callogenase by extraction in pH 6.7 buffer, followed by hydroxylapatite chromatography with a 0.1-0.2 M phosphate gradient, then Sephadex G-75 gel filtration with 0.05M phosphate pH 6.7, dialysis and a second hydroxylapatite chromatography (gradient elution with 0.1M 0.3M phosphate, pH 6.7). It has proteinase and esterase activity and is assayed by hydrolysing N-benzoyl-L-arginine methyl ester. [Mitchell & Harrington J Biol Chem 243 4683 1968, Methods Enzymol 19 635 1970.]
CLOSTRIPAIN Preparation Products And Raw materials
Raw materials
Preparation Products
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