MANZAMINE A

Product Name: MANZAMINE A
CAS No.: 104196-68-1
Chemical Name: MANZAMINE A
Synonyms: MANZAMINE A;Keramamine A;1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-
CBNumber: CB9838727
Molecular Formula: C36H44N4O
Formula Weight: 548.76
MOL File: 104196-68-1.mol

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MANZAMINE A Property

Melting point:: ＞240(disassembly)
Boiling point:: 756.6±60.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: -20°
solubility: Soluble in DMSO (up to 25 mg/ml).
form: Off white to yellow solid.
pka: 13.58±0.40(Predicted)
color: Off-White to Pale Yellow
optical activity: +5020 (CHCl3)
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21444
Product name: Manzamine A
Purity: ≥98%
Packaging: 500μg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 21444
Product name: Manzamine A
Purity: ≥98%
Packaging: 1mg
Price: $232
Updated: 2024/03/01

TRC

Product number: M186003
Product name: ManzamineA
Packaging: 2.5mg
Price: $795
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CN2-0438-C500
Product name: ManzamineA
Purity: ≥98%(HPLC)
Packaging: 500μg
Price: $140
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546096
Product name: Manzamine A
Purity: >98%
Packaging: 1mg
Price: $365.5
Updated: 2021/12/16

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MANZAMINE A Chemical Properties,Usage,Production

Description

Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis?in vivo2. Manzamine A displays neuritogenic activity3?and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4.

Uses

Manzamine A is a β-Carboline alkaloid with anti-inflammatory.

Definition

ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).

storage

+4°C

References

1) Kallifatidis?et al. (2013),?The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells; Mar. Drugs,?11?3500 2) Eguchi?et al. (2013),?Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo; Bioorg. Med. Chem.,?21?3831 3) Zhang?et al. (2008),?Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. Igens (Thiele, 1899); Chem. Pharm. Bull.,?56?866 4) Hamann?et al. (2007),?Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease; J. Nat. Prod.,?70 139

MANZAMINE A Preparation Products And Raw materials

Raw materials

Preparation Products

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MANZAMINE A Suppliers

China 38 Switzerland 2 United Kingdom 3 United States 8 Global 51

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

Focus Biomolecules

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Email: sales@focusbiomolecules.com
Country: United States
ProdList: 1284
Advantage: 58

Cayman Chemical Company

Tel: --
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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

2A PharmaChem USA

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Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

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Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

104196-68-1, MANZAMINE ARelated Search:

OUABAIN OCTAHYDRATE AR-A014418 SB216763 Ethacrynic acid 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE SB 415286 1-AZAKENPAULLONE KAHWEOL SEDANOLIDE S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE CAFESTOL 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE (R)-TERT-LEUCINOL 3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-OL 4-PYRIDIN-2-YL-BUTYLAMINE MANZAMINE A N,N-DIBUTYL-2-ETHYLHEXYLAMINE manzamine F

MANZAMINE A

1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-

Keramamine A

104196-68-1

C36H44N4O