description Stability and Reactivity: HUMAN USE AND EXPERIENCE Metabolism/Pharmacokinetics
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Sodium chloroacetate

description Stability and Reactivity: HUMAN USE AND EXPERIENCE Metabolism/Pharmacokinetics
Product Name
Sodium chloroacetate
CAS No.
3926-62-3
Chemical Name
Sodium chloroacetate
Synonyms
sma;SODIUM MONOCHLOROACETATE;sodiuM 2-chloroacetate;smca;SODIUM MONOCHLORACETATE;CHLOROACETIC ACID SODIUM SALT;SMN;SMA3;SMA2;SMA1
CBNumber
CB9853591
Molecular Formula
C2H2ClNaO2
Formula Weight
116.48
MOL File
3926-62-3.mol
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Sodium chloroacetate Property

Melting point:
199 °C (dec.)(lit.)
Density 
1.87[at 20℃]
vapor pressure 
0.001Pa at 20℃
Flash point:
270°C
storage temp. 
-20°C
solubility 
820g/l
form 
Crystalline Powder
color 
White
PH
4.5-9.0 (50g/l, H2O, 20℃)
Water Solubility 
440 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,2112
BRN 
3597157
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
-3.8 at 20℃
CAS DataBase Reference
3926-62-3(CAS DataBase Reference)
EPA Substance Registry System
Sodium chloroacetate (3926-62-3)
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Safety

Hazard Codes 
T,N
Risk Statements 
25-38-50-36
Safety Statements 
22-37-45-61-26
RIDADR 
UN 2659 6.1/PG 3
WGK Germany 
2
RTECS 
AG1400000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29154000
Toxicity
LD50 orally in Rabbit: 95 mg/kg LD50 dermal Rat > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.20293
Product name
Sodium chloroacetate
Purity
for synthesis
Packaging
100g
Price
$40
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20293
Product name
Sodium chloroacetate
Purity
for synthesis
Packaging
500g
Price
$53.6
Updated
2024/03/01
Sigma-Aldrich
Product number
291773
Product name
Sodium chloroacetate
Purity
98%
Packaging
1kg
Price
$55
Updated
2024/03/01
Sigma-Aldrich
Product number
291773
Product name
Sodium chloroacetate
Purity
98%
Packaging
3kg
Price
$134
Updated
2024/03/01
Alfa Aesar
Product number
A12379
Product name
Sodium chloroacetate, 98%
Packaging
250g
Price
$22.9
Updated
2024/03/01
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Sodium chloroacetate Chemical Properties,Usage,Production

description

Sodium chloroacetate is a white colored powdered solid. It is soluble in water. It may be toxic ingestion or inhalation. It is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.

In one study systemic effects to Sprague-Dawley rats (M/F, numbers per group not indicated) given single doses of sodium chloroacetate at 94, 282, or 470 mg/kg bw demonstrated increased sodium concentration in urine, increased potassium concentration in plasma, and reduced glutathione level in the liver at the highest dose; 2/3 of males died within 24 hours of treatment in the middle and high dose groups.

Stability and Reactivity:

Sodium chloroacetate is stable at normal temperatures and  pressures. Incompatible with oxidizing agents, reducing  agents.

HUMAN USE AND EXPERIENCE

There are a number of case studies of the parent compound,  monochloroacetic acid (MCA), involving corrosion of skin and  eyes and fatalities related to skin absorption of toxicologically  significant amounts of MCA and a health-based target  concentration of 0.1 mg/L was calculated for MCA in drinking  water although Health Canada and Environment Canada have  categorized MCA as not entering the environment at levels that  may be hazardous to human health. There are, however, no  similar data or epidemiological reports for sodium  chloroacetate.

Metabolism/Pharmacokinetics

After absorption, monochloroacetic acid (parent compound  CAS 79-11-8) is converted to thiodiacetic acid and glycolic acid  and is accumulated in the liver and kidneys of rats.Metabolism of sodium monochloroacetate is expected to have a  similar pharmacokinetic profile.

Chemical Properties

Sodium chloroacetate is a white crystalline powder. It is soluble in water. It may be toxic ingestion or inhalation.
Sodium chloroacetate is a reactive and toxic material, so it is hydrolyzed to glycolic acid nearly quantitatively at the end of the production cycle. Chloroacetic acid always contains traces of dichloroacetic acid, a toxic and unreactive material that appears on the California Prop.65 list.

Uses

Sodium chloroacetate is the sodium salt of chloroacetic acid. It is used to prepare weed killers, dyes, vitamins and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor. Sodium dihydroxyethyltallow glycinate is the condensation product of dihydroxyethyl tallow amine and sodiumchloroacetate.It is used as a thickeningagent and asurfactant.

Uses

Sodium chloroacetate is used to prepare dyes and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor.

General Description

Chloroacetic acid sodium salt is a white colored powdered solid. Chloroacetic acid sodium salt is soluble in water.Chloroacetic acid sodium salt may be toxic ingestion or inhalation. Sodium chloroacetate is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.

Air & Water Reactions

Chloroacetic acid sodium salt is soluble in water.

Reactivity Profile

Salts, basic, such as Chloroacetic acid sodium salt, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Actin plays an important role in cell motility, structure and integrity. Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and helps in vascular smooth muscle cell contraction. The encoded protein modulates the expression of c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Mutation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD).

Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Cland NazO. Used as an herbicide

Sodium chloroacetate Preparation Products And Raw materials

Raw materials

Chloroacetic acid

Preparation Products

Sodium carboxyl methylstarch castor oil type amphoteric surfactant JHZ-103 Betaine sodium oleyl sarcosinate laurylamide carboxyamine propionate JHZ-102 cocoyl coarboxy methyl imidazoline acetat XCG-CA-2 type Vat Red 41 Nitromethane Dimethyl malonate dimethyl dodecyl thioic propylene betaine Sodium carboxymethyl cellulose Cocoamidopropyl betaine sulfate AEC glyceryl ethercarboxylic acid salt Butyl 2,4-dichlorophenoxyacetate Epalrestat Cocamidopropyl betaine N-tetradecyl glycine sodium salt 2,2-Dibromo-2-cyanoacetamide Alkyl dimethyl betaine Isoprothiolane Cyanoacetic acid Iminodiacetic acid Dodecyl dimethyl betaine 2,4-Dichlorophenoxyacetic acid Diethyl malonate N-Methyliminodiacetic acid Nitrilotriacetic acid n-Butyl cyanoacetate Cocamidopropyl betaine Malonic acid 2,4-Dichlorophenoxybutyric acid Ethyl cyanoacetate Ethylenediaminetetraacetic acid
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Sodium chloroacetate Suppliers

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View Lastest Price from Sodium chloroacetate manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Sodium chloroacetate 3926-62-3
Price
US $10.00-2.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-28
Hebei Weibang Biotechnology Co., Ltd
Product
Sodium chloroacetate 3926-62-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2023-02-16
Hebei Mojin Biotechnology Co., Ltd
Product
Sodium chloroacetate 3926-62-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-10

3926-62-3, Sodium chloroacetateRelated Search:

(Z)-2-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)acetic acid alpha-Methylcinnamylaldehyde 3-Thiazolidineacetic acid, 5-[(2Z)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5E)- Epalrestat Impurity 4 ethyl 2-((E)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetate Epalrestat iMpurity 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid Epalrestat Glycine, N-(dithiocarboxy)- (6CI,7CI,8CI,9CI) (Z)-2-methyl-3-phenylacrylaldehyde (5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID (2,4-DIOXO-1,3-THIAZOLIDIN-3-YL)ACETIC ACID 3-Thiazolidineaceticacid, 4-oxo-2-thioxo-, ethyl ester (Z,Z)-5-(2-Methyl-3-phenyl-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5E)- Chloroacetic acid Sodium acetate trihydrate Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-1H-imidazole-1-ethanol 2-norcoco alkyl derivs. and sodium hydroxide

  • Aceticacid,chloro-,sodiumsalt
  • chloro-aceticacisodiumsalt
  • chloroctansodny
  • dowdefoliant
  • Chloroacetic acid sodium salt,98%
  • Sodium chloroacetate, synthesis grade
  • Chloroacetic acid sodiuM salt, 98% 5GR
  • SMA1
  • SMA2
  • SMA3
  • SMN
  • sodiuM 2-chloroacetate
  • Chloroacetic Acid MonosodiuM Salt, Granular
  • SodiuM chloroacetat
  • FREE SAMPLE NCV SODIUM MONOCHLOROACEETAT E
  • Natriumchloracetat
  • Sodium salt of chloroacetic acid
  • Chloroacetate sodium
  • sodium salt of chloroacetic acid sodium chloroacetate
  • monoxone
  • sma
  • smca
  • CHLOROACETIC ACID MONOSODIUM SALT
  • CHLOROACETIC ACID SODIUM SALT
  • SODIUM MONOCHLORACETATE
  • SODIUM MONOCHLOROACETATE
  • SODIUM CHLOROACETATE
  • Sodum chloroacetate
  • Monochloroacetic Acid Sodium
  • SodiumChloroacetate,>96%
  • Sodiumchloroacetate,98%
  • Sodium chloroacetate 3926-62-3
  • 3926-62-3 Chloroacetic acid sodium salt
  • Acetic acid, 2-chloro-, sodium salt (1:1)
  • Sodium α-Chloroacetate
  • Sodium a-Chloroacetate
  • SODIUM MONOCHLORO ACETATE (SMCA)
  • SODIUM MONOCHLOROACETATE For Synthesis
  • Monoclonal Anti-Actin, α-Smooth Muscle - FITC antibody produced in mouse
  • Monoclonal Anti-SMN1 antibody produced in mouse
  • Monoclonal Anti-Actin, α-Smooth Muscle - Alkaline Phosphatase antibody produced in mouse
  • Monoclonal Anti-Actin, α-Smooth Muscle - Cy3? antibody produced in mouse
  • 3926-62-3
  • C2Cl1H2Na1O2
  • ClCH2CO2Na
  • ClCH2COONa
  • C2H2CINaO2
  • C2H2ClNaO2
  • C2H2ClO2Na
  • Synthetic Reagents
  • Inorganic Salts