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2-Chlorotrityl chloride

Product Name
2-Chlorotrityl chloride
CAS No.
42074-68-0
Chemical Name
2-Chlorotrityl chloride
Synonyms
2-CHLOROTRITYL CHLORIDE RESIN;CTC resin;2-CHLOROTRITYL RESIN;2-CHLOROTRITYLCHLORIDE POLYMER RESIN;2CTC Resin;2-CHLOROPHENYLDIPHENYLMETHYL CHLORIDE;CL-TRT(2-CL)-RESIN;1-chloro-2-(chlorodiphenylmethyl)benzene;(chloro(2-chlorophenyl)Methylene)dibenzene;BR-1060
CBNumber
CB9853612
Molecular Formula
C19H14Cl2
Formula Weight
313.22
MOL File
42074-68-0.mol
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2-Chlorotrityl chloride Property

Melting point:
130-135 °C
Boiling point:
421.3±40.0 °C(Predicted)
Density 
1.222±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform, methanol and dichloromethane, insoluble in water
form 
Powder
color 
Pale yellow crystalline powder
BRN 
1983914
CAS DataBase Reference
42074-68-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-24/25-22
RIDADR 
3261
WGK Germany 
3
F 
10-21
HS Code 
2903 99 80
HazardClass 
8
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H290May be corrosive to metals

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P234Keep only in original container.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.51061
Product name
2-Chlorotrityl chloride
Purity
Novabiochem?
Packaging
25g
Price
$219
Updated
2024/03/01
Sigma-Aldrich
Product number
26569
Product name
2-Chlorotrityl chloride
Purity
≥97.0% (AT)
Packaging
10g
Price
$320
Updated
2024/03/01
TCI Chemical
Product number
D2504
Product name
2-Chlorotrityl Chloride
Purity
>98.0%(HPLC)
Packaging
25g
Price
$147
Updated
2024/03/01
Alfa Aesar
Product number
044407
Product name
2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g
Packaging
2g
Price
$78.65
Updated
2024/03/01
Alfa Aesar
Product number
044407
Product name
2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g
Packaging
10g
Price
$326
Updated
2024/03/01
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2-Chlorotrityl chloride Chemical Properties,Usage,Production

Chemical Properties

off-white to yellow or brown beads

Uses

2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. In addition, it serves as a protecting group reagent for carboxylic acids forming esters.

Application

2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.

Preparation

2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product.

Biotechnological Applications

The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. It is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. Peptides UBI-8 and UBI-9 were synthesized by Fmoc-solid phase chemistry using a 2-chlorotrityl chloride linker-resin. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed.

2-Chlorotrityl chloride Preparation Products And Raw materials

Raw materials

Ethyl 2-Chlorobenzoate Bromobenzene 2-Chlorobenzoic acid PARA TOLUENE MAGNESIUM METHOXIDE Benzhydrol Thionyl chloride

Preparation Products

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2-Chlorotrityl chloride Suppliers

Americas 1 Belgium 1 Canada 3 China 259 Europe 3 France 1 Germany 6 India 17 Japan 4 Russia 1 Slovakia 1 South Korea 1 Switzerland 4 Ukraine 1 United Kingdom 11 United States 42 Global 356
Acros Organics
Tel
--
Fax
--
Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81
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View Lastest Price from 2-Chlorotrityl chloride manufacturers

Shanghai Qyubiotech Co., Ltd.
Product
2-Chlorotrityl chloride 42074-68-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%+
Supply Ability
10000kgs per Month
Release date
2023-08-16
Ningxia Jinhua Chemical Co.,Ltd
Product
2-CHLOROTRITYL CHLORIDE 42074-68-0
Price
US $0.00/Kg/Drum
Min. Order
25KG
Purity
99.5%
Supply Ability
100 tons
Release date
2020-07-15
Changde Changlian Chemical Co., Ltd.
Product
2-CHLOROTRITYL CHLORIDE 42074-68-0
Price
US $0.00/Kg/Drum
Min. Order
25KG
Purity
99.5%
Supply Ability
100 tons
Release date
2020-07-15

42074-68-0, 2-Chlorotrityl chlorideRelated Search:

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  • 2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 1.0 to 1.4 mmol/g
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  • CL-TRT(2-CL)-RESIN
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  • BARLOS RESIN
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  • RINK AMIDE 2-CHLOROTRITYL RESIN
  • RINK-BERNATOWITZ-AMIDE BARLOS RESIN
  • RINK AMIDE BARLOS RESIN
  • PL CL-TRT-CL RESIN
  • NH2-SAL-TRT(2-CL)-RESIN
  • O-CHLOROTRITYL CHLORIDE
  • O-CHLORPHENYL-DIPHENYL-CHLOROMETHANE
  • TRT(2-CL)-CL
  • Chloro-(o-chlorophenyl)diphenylmethane
  • 1-chloro-2-(chlorodiphenylmethyl)benzene
  • Diphenyl(2-Chlorophenyl)Chloromethane
  • O-CHLORPHENYL-DIPHENYL-CHLOROMETHANE(CLOTRIMAZOLE INTERMEDIATE )
  • 100-200mesh,1%DVB,1.0-1.6mmol/g]
  • 2-Chlorotritylchlorideresine
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  • BR-1060
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  • 2-Chlorotrityl Chloride, 95.0%(T)
  • 2-Chlorotrityl chloride, polymer-bound 200-400 mesh, extent of labeling: 1.0-1.5 mmol/g Cl loading, 1 % cross-linked
  • 2-Chlorotriphenylmethyl chloride resin
  • 2-Chlorotrityl chloride resin(1.0-1.2 meq/g, 200-400 mesh)
  • 2-Chlorotrityl chloride resin(1.0-2.0 meq/g, 100-200 mesh)
  • 2-Chlorotrityl chloride resin(1.0-1.8 meq/g, 100-200 mesh)
  • 2-Chlorotrityl chloride resin(0.3-0.8 meq/g, 200-400 mesh)
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  • 2,ALPHA-DICHLOROBENZHYDRYL-POLYSTYRENE CROSSLINKED WITH DIVINYLBENZENE
  • 2,ALPHA-DICHLOROBENZHYDRYLPOLYSTYRENE DIVINYLBENZENE COPOLYMER
  • 2-CL-(TRT)-CL RESIN
  • 2-CLTRT RESIN
  • 2CT-CL RESIN
  • 2CT-CL RESIN 100
  • 2CT-CL RESIN 200
  • 2-CHLOROTRITYL RESIN
  • 2-CHLOROTRIPHENYL CHLOROMETHANE
  • 2-CHLOROTRIPHENYL CHLOROMETHANE RESIN
  • 2-CHLOROTRITYL KNORR RESIN
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