2-Chlorotrityl chloride

Product Name: 2-Chlorotrityl chloride
CAS No.: 42074-68-0
Chemical Name: 2-Chlorotrityl chloride
Synonyms: 2-CHLOROTRITYL CHLORIDE RESIN;CTC resin;2-CHLOROTRITYL RESIN;2-CHLOROTRITYLCHLORIDE POLYMER RESIN;2CTC Resin;2-CHLOROPHENYLDIPHENYLMETHYL CHLORIDE;CL-TRT(2-CL)-RESIN;1-chloro-2-(chlorodiphenylmethyl)benzene;(chloro(2-chlorophenyl)Methylene)dibenzene;BR-1060
CBNumber: CB9853612
Molecular Formula: C19H14Cl2
Formula Weight: 313.22
MOL File: 42074-68-0.mol

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2-Chlorotrityl chloride Property

Melting point:: 130-135 °C
Boiling point:: 421.3±40.0 °C(Predicted)
Density: 1.222±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in Chloroform, methanol and dichloromethane, insoluble in water
form: Powder
color: Pale yellow crystalline powder
BRN: 1983914
CAS DataBase Reference: 42074-68-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-24/25-22
RIDADR: 3261
WGK Germany: 3
F: 10-21
HS Code: 2903 99 80
HazardClass: 8
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H290May be corrosive to metals

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P234Keep only in original container.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.51061
Product name: 2-Chlorotrityl chloride
Purity: Novabiochem?
Packaging: 25g
Price: $219
Updated: 2024/03/01

Sigma-Aldrich

Product number: 26569
Product name: 2-Chlorotrityl chloride
Purity: ≥97.0% (AT)
Packaging: 10g
Price: $320
Updated: 2024/03/01

TCI Chemical

Product number: D2504
Product name: 2-Chlorotrityl Chloride
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $147
Updated: 2024/03/01

Alfa Aesar

Product number: 044407
Product name: 2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g
Packaging: 2g
Price: $78.65
Updated: 2024/03/01

Alfa Aesar

Product number: 044407
Product name: 2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g
Packaging: 10g
Price: $326
Updated: 2024/03/01

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2-Chlorotrityl chloride Chemical Properties,Usage,Production

Chemical Properties

off-white to yellow or brown beads

Uses

2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. In addition, it serves as a protecting group reagent for carboxylic acids forming esters.

Application

2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.

Preparation

2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Biotechnological Applications

The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. It is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. Peptides UBI-8 and UBI-9 were synthesized by Fmoc-solid phase chemistry using a 2-chlorotrityl chloride linker-resin. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed.

2-Chlorotrityl chloride Preparation Products And Raw materials

Raw materials

Ethyl 2-Chlorobenzoate Bromobenzene 2-Chlorobenzoic acid PARA TOLUENE MAGNESIUM METHOXIDE Benzhydrol Thionyl chloride

Preparation Products

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2-Chlorotrityl chloride Suppliers

Americas 1 Belgium 1 Canada 3 China 261 Europe 3 France 1 Germany 6 India 17 Japan 4 Russia 1 Slovakia 1 South Korea 1 Switzerland 4 Ukraine 1 United Kingdom 11 United States 42 Global 358

Sichuan Hainuowei Technology Co. Ltd.

Tel: 13708085536
Fax: QQ : 121102042
Email: hanovichem@163.com
Country: China
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Tianjin Nuohan Chemical Co., Ltd.

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Shanghai QianJin Chemical Technology Co., Ltd

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Shandong fen Boyu Biotechnology Co.,LTD

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Email: market03@meryer.com
Country: China
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
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Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
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Country: China
ProdList: 44689
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GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
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View Lastest Price from 2-Chlorotrityl chloride manufacturers

Ningxia Jinhua Chemical Co.,Ltd

Product: 2-CHLOROTRITYL CHLORIDE 42074-68-0
Price: US $0.00/Kg/Drum
Min. Order: 25KG
Purity: 99.5%
Supply Ability: 100 tons
Release date: 2020-07-15

Changde Changlian Chemical Co., Ltd.

Product: 2-CHLOROTRITYL CHLORIDE 42074-68-0
Price: US $0.00/Kg/Drum
Min. Order: 25KG
Purity: 99.5%
Supply Ability: 100 tons
Release date: 2020-07-15

Shanghai Qyubiotech Co., Ltd.

Product: 2-Chlorotrityl chloride 42074-68-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%+
Supply Ability: 10000kgs per Month
Release date: 2023-08-16

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