Aliskiren
- Product Name
- Aliskiren
- CAS No.
- 173334-57-1
- Chemical Name
- Aliskiren
- Synonyms
- CS-201;SPP 100;Rasilez;Tekturna;CGP60536B;CGP 60536;Aliskiren;Aliskiren Base;Aliskiren (USAN);Aliskiren, >=98%
- CBNumber
- CB9966226
- Molecular Formula
- C30H53N3O6
- Formula Weight
- 551.76
- MOL File
- 173334-57-1.mol
Aliskiren Property
- Melting point:
- 98-99 °C
- Boiling point:
- 748.4±60.0 °C(Predicted)
- Density
- 1.067±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO : 100 mg/mL (181.24 mM; Need ultrasonic)
- form
- Powder
- pka
- 9.49(at 25℃)
- CAS DataBase Reference
- 173334-57-1(CAS DataBase Reference)
Safety
- Hazardous Substances Data
- 173334-57-1(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS023114
- Product name
- Aliskiren
- Packaging
- 10MG
- Price
- $209
- Updated
- 2024/03/01
- Product number
- FA134549
- Product name
- 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0443
- Product name
- Aliskiren
- Purity
- 99.16%
- Packaging
- 5mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- 158321
- Product name
- 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
- Packaging
- 0.500g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0443
- Product name
- Aliskiren
- Purity
- 99.16%
- Packaging
- 10mg
- Price
- $132
- Updated
- 2021/12/16
Aliskiren Chemical Properties,Usage,Production
Description
Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .
Originator
Novartis (Switzerland)
Uses
An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive
Uses
liquid crystal intermediate
Definition
ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.
brand name
Tekturna
General Description
Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.
Aliskiren Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aliskiren manufacturers
- Product
- Aliskiren 173334-57-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-04-16
- Product
- Aliskiren 173334-57-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-04-19
- Product
- Aliskiren 173334-57-1
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-08-02