ChemicalBook > CAS DataBase List > Aliskiren

Aliskiren

Product Name
Aliskiren
CAS No.
173334-57-1
Chemical Name
Aliskiren
Synonyms
CS-201;SPP 100;Rasilez;Tekturna;CGP60536B;CGP 60536;Aliskiren;Aliskiren Base;Aliskiren (USAN);Aliskiren, >=98%
CBNumber
CB9966226
Molecular Formula
C30H53N3O6
Formula Weight
551.76
MOL File
173334-57-1.mol
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Aliskiren Property

Melting point:
98-99 °C
Boiling point:
748.4±60.0 °C(Predicted)
Density 
1.067±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO : 100 mg/mL (181.24 mM; Need ultrasonic)
form 
Powder
pka
9.49(at 25℃)
color 
White to light yellow
CAS DataBase Reference
173334-57-1(CAS DataBase Reference)
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Safety

Hazardous Substances Data
173334-57-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS023114
Product name
Aliskiren
Packaging
10MG
Price
$209
Updated
2024/03/01
ChemScene
Product number
CS-0443
Product name
Aliskiren
Purity
99.16%
Packaging
50mg
Price
$240
Updated
2021/12/16
ApexBio Technology
Product number
A3153
Product name
Aliskiren
Packaging
1g
Price
$314
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA134549
Product name
5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
Packaging
2g
Price
$350
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611736
Product name
Aliskiren
Packaging
10mg
Price
$460.7
Updated
2021/12/16
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Aliskiren Chemical Properties,Usage,Production

Description

Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .

Originator

Novartis (Switzerland)

Uses

An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive

Uses

liquid crystal intermediate

Definition

ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.

brand name

Tekturna

General Description

Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.

Aliskiren Preparation Products And Raw materials

Raw materials

Preparation Products

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Aliskiren Suppliers

Canada 1 China 157 India 8 United Kingdom 2 United States 18 Global 186
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Molekula Ltd
Tel
--
Fax
--
Email
info@molekula.com
Country
United Kingdom
ProdList
4060
Advantage
50
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View Lastest Price from Aliskiren manufacturers

Apeloa production Co.,Limited
Product
Aliskiren 173334-57-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000
Release date
2024-06-19
Hebei Weibang Biotechnology Co., Ltd
Product
Aliskiren 173334-57-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
Aliskiren 173334-57-1
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20

173334-57-1, AliskirenRelated Search:

Tris(hydroxymethyl)aminomethane Glycine Isopropyl alcohol 6-Aminocaproic acid POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 4-Methoxybenzyl cyanide ISOPROPYL LAURATE p-Anisidine 4-Methoxyphenol p-Anisaldehyde CHLOROPHOSPHONAZO III Guaiacol ALTRENOGEST Anisole (Trifluoromethoxy)benzene Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- Aliskiren hemifumarate Aliskiren inter-8

  • Aliskiren
  • (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide
  • CGP 60536
  • CGP60536B
  • Rasilez
  • SPP 100
  • Tekturna
  • (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide
  • (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide
  • ALISKIREN FREE BASE
  • (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-Methoxybenzyl)-5-aMino-N-(2-carbaMoyl-2-Methylpropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide
  • Aliskiren (CGP 60536)
  • Aliskiren (USAN)
  • CGP 60536;CGP60536B;SPP 100
  • CS-201
  • CGP-60536; CGP60536; TEKTURNA;SPP 100
  • (2S,4S,5S,7S)-7-(4-Methoxy-3-(3-Methoxypropoxy)benzyl)-5-aMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-MethylnonanaMide
  • Aliskiren Base
  • 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide fumarate
  • Aliskiren, >=98%
  • 5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypr
  • Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-
  • Aliskiren USP/EP/BP
  • (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide
  • Aliskiren 99% CAS NO.173334-57-1
  • Aliskiren 100 μg/ml Acetonitrile
  • 173334-57-1
  • C30H53N3O6HCl
  • C30H53N3O6
  • C34H57N3O10
  • C30H53N3O6C4H4O4
  • API
  • Amines
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chemical Amines
  • Aliskiren intermediates