CATHEPSIN L

Product Name: CATHEPSIN L
CAS No.: 60616-82-2
Chemical Name: CATHEPSIN L
Synonyms: Native Human Cathepsin L;cathepsin l from human liver;Aldrichina grahami cysteine proteinase;Pacific whiting surimi wash water proteinase;Cathepsin L from human liver >=0.5 units/mg protein, solution
CBNumber: CB9972423
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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CATHEPSIN L Property

storage temp.: -20°C
form: solution
biological source: human liver
Specific Activity: ≥0.5units/mg protein

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Safety

Hazard Codes: B
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6854
Product name: Cathepsin L from human liver
Purity: ≥0.5?units/mg protein, solution
Packaging: 25μg
Price: $431
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: ENZ0000157
Product name: CATHEPSIN L (HUMAN)
Purity: 95.00%
Packaging: 5MG
Price: $501.94
Updated: 2021/12/16

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CATHEPSIN L Chemical Properties,Usage,Production

Uses

The most powerful of the lysosomal proteinases. It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates.

Biological Activity

Cathepsin L (CTSL) exhibits endopeptidase activity and breaks peptide bonds with aromatic residues. This enzyme is functional at pH 3.0–6.5 with thiol compounds. Elastin, collagen, and α-1 protease inhibitors act as substrates for cathepsin L (CTSL). CTSL cleaves several proteins including enzymes, receptors, and transcription factors. It is involved in antigenic peptide production and controls B-cells homeostasis. It is associated with myofibril necrosis and tumor progression. Increased expression of CTSL promotes metastasis and relates to poor prognosis in cancer patients. Increased expression of CTSL is observed in breast cancer. CTSL is implicated in glioblastoma multiforme (GBM), middle east respiratory syndrome (MERS), gingival overgrowth, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates.

CATHEPSIN L Preparation Products And Raw materials

Raw materials

Preparation Products

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CATHEPSIN L Suppliers

China 17 Switzerland 1 United States 4 Global 22

Sigma-Aldrich

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60616-82-2, CATHEPSIN LRelated Search:

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cathepsin l from human liver

Pacific whiting surimi wash water proteinase

Aldrichina grahami cysteine proteinase

Native Human Cathepsin L

Cathepsin L from human liver >=0.5 units/mg protein, solution

60616-82-2

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