3,5-Difluorobenzyl bromide Chemical Properties

Boiling point:

65 °C4.5 mm Hg(lit.)

Density 

1.6 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.521(lit.)

Flash point:

179 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

clear liquid

color 

Colorless to Orange to Green

Specific Gravity

1.62

Sensitive 

Lachrymatory

BRN 

7422062

InChI

InChI=1S/C7H5BrF2/c8-4-5-1-6(9)3-7(10)2-5/h1-3H,4H2

InChIKey

KVSVNRFSKRFPIL-UHFFFAOYSA-N

SMILES

C1(CBr)=CC(F)=CC(F)=C1

CAS DataBase Reference

141776-91-2(CAS DataBase Reference)

NIST Chemistry Reference

3,5-Difluorobenzyl bromide(141776-91-2)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36-43

Safety Statements 

26-36/37/39-45-27-36/37

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

Hazard Note 

Corrosive/Lachrymatory

HazardClass 

8

PackingGroup 

III

HS Code 

29039990

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,5-Difluorobenzyl bromide Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

3,5-Difluorobenzyl bromide is a kind of important medicine intermediate. 

Synthesis

Triphenylphosphine (2.75 g, 10.5 mmol) and carbon tetrabromide (3.48 g, 10.5 mmol) were added to a dry reaction flask followed by the addition of 25 mL of ether and the resulting mixture was stirred at room temperature for 30 min, then an ether solution of 3,5-difluorobenzenemethanol (10.5 mmol) was slowly added to the above mentioned system and the reaction mixture was continued to be stirred at 25??C for 40 minutes. At the end of the reaction, petroleum ether was added to the reaction system, and a white precipitate of triphenylphosphine oxide was observed. Most of the triphenylphosphine oxide was removed by filtration, and the obtained filtrate was concentrated in vacuum, and finally, hexane was used as the eluent, and the residue was separated and purified by silica gel chromatography to obtain the target product of 3,5-difluorobenzyl bromide.

3,5-Difluorobenzyl bromide(141776-91-2)Related Product Information

• 2,3-Difluorobenzyl bromide
• Rocuronium bromide
• Dibromomethane
• Sodium bromate
• 1,2-Difluorobenzene
• Ethidium bromide
• Allyl bromide
• 4-Trifluoromethylbenzyl chloride
• Vecuronium bromide
• 4-Bromobenzotrifluoride
• Dimidium bromide
• Decabromodiphenyl Ethane
• Ethyl bromodifluoroacetate
• 3,5-DIFLUOROBENZYL CHLORIDE
• 3,5-Difluoronitrobenzene
• Methyl bromide
• 2,3,5,6-TETRAFLUOROBENZYL BROMIDE
• 2,3,4,5-TETRAFLUOROBENZYL BROMIDE