1-METHOXY-2-METHYL-2-PROPANOL Chemical Properties

Boiling point:

115-116 °C (lit.)

Density 

0.892 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.4044(lit.)

Flash point:

82 °F

storage temp. 

2-8°C

form 

Liquid

pka

14.56±0.29(Predicted)

color 

Clear colorless

LogP

0.069 (est)

CAS DataBase Reference

3587-64-2

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

26-36

RIDADR 

UN 1987 3/PG 3

WGK Germany 

3

HazardClass 

3

PackingGroup 

III

HS Code 

29094980

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-METHOXY-2-METHYL-2-PROPANOL Usage And Synthesis

Synthesis

1. Catalyst pretreatment: 0.037 mmol of Zr catalyst was added to a 25 mL round-bottomed flask and heated at 150°C under vacuum overnight to remove the absorbed water. 2. Reaction system preparation: 5mL of methanol was added to the flask and sonicated for 15 min. 3. Addition of reactants: 1 mmol of propylene oxide was added. 4. 4. Reaction condition setting: Place the reaction mixture in a bath preheated to 50°C with magnetic stirring. 5. Catalyst activation (if applicable): 2.5 mL of acetone was added as solvent and after sonication of the catalyst, 1.0 mmol of amine and 1.0 mmol of styrene oxide were added sequentially. 6. Reaction termination and product recovery: At the end of the reaction, the catalyst was washed thoroughly with methanol to recover the adsorbed products. 7. Product purification: The product was purified using silica gel. 7. Product purification: The product was purified by rapid column chromatography using silica gel column chromatography with hexane:methylene chloride as eluent. 8. Reaction monitoring: Aliquots of the reaction mixture were withdrawn periodically with a syringe, diluted with methanol and immediately analyzed by GC (Agilent 6890 network GC system), and the product concentration was determined by a calibration curve.

References

[1] Journal of Molecular Catalysis A: Chemical, 2016, vol. 425, p. 332 - 339
[2] Patent: US2886600, 1957,
[3] Journal of Molecular Structure, 1991, vol. 243, p. 111 - 122
[4] Patent: US2886600, 1957,

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