Basic information Safety Supplier Related

5-Nitro-2-furoic acid

Basic information Safety Supplier Related

5-Nitro-2-furoic acid Basic information

Product Name:
5-Nitro-2-furoic acid
Synonyms:
  • RARECHEM AL BO 1619
  • 2-Furancarboxylic acid, 5-nitro-
  • 2-furancarboxylicacid,5-nitro
  • 2-Furoic acid, 5-nitro-
  • 5-Nitro-2-furylcarboxylic acid
  • 2-Carboxy-5-nitrofuran 5-Nitro-2-furoic Acid
  • 5-Nitro-2-huraldehyde carboxylic acid
  • 5-NITRO-2-FURANCARBOXYLIC ACID
CAS:
645-12-5
MF:
C5H3NO5
MW:
157.08
EINECS:
211-432-6
Product Categories:
  • Furans
  • Miscellaneous
  • API intermediates
Mol File:
645-12-5.mol
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5-Nitro-2-furoic acid Chemical Properties

Melting point:
185-189 °C (lit.)
Boiling point:
281.7°C (rough estimate)
Density 
1.8109 (rough estimate)
refractive index 
1.4798 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.06±0.10(Predicted)
color 
White to Light Yellow
Water Solubility 
Slightly soluble in water.
BRN 
139373
CAS DataBase Reference
645-12-5(CAS DataBase Reference)
NIST Chemistry Reference
5-Nitrofuran-2-carboxylic acid(645-12-5)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
68-36/37/38-40
Safety Statements 
37/39-36/37-36-22
WGK Germany 
3
RTECS 
LV2012000
HS Code 
2932.19.5100

MSDS

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5-Nitro-2-furoic acid Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

5-Nitro-2-furoic acid is a representative of 2-substituted 5-nitrofurans. A number of nitrofurans have been used as antibacterial, antiprotozoal, and anthelmintic drugs in humans and animals. 2-Substituted 5-nitrofurans have been used worldwide as human and veterinary medicines, food preservatives, and feed additives, and they are utilized in human medicine as antibacterial agents. Therefore, the relationship between the antibacterial effect and the mutagenicity of these compounds and their oxidized metabolites is important. Comparison of the antibacterial effects and genotoxic potencies of nitrofuran drugs and their oxidative metabolites may provide a new direction for selecting nitrofuran drugs for human use.

Uses

5-Nitro-2-furoic acid was used in the preparation of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has also been studied.

General Description

The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has been studied.

Environmental Fate

5-Nitro-2-furoic acid is a yellow crystalline powder with molecular weight of 157.08 g mol-1 and density of 1.72 g cm-3. The boiling point is 332.4 ℃ and the melting point is 185.00– 189.00 ℃ at 760 mm Hg. Vapor pressure is 5.83E-05 mm Hg at 25 ℃ and enthalpy of vaporization is 60.71 kJ mol-1. 5-Nitro-2-furoic acid is very soluble in water. It is stable under normal temperature and pressure.

Toxicity evaluation

The toxicological properties of this compound have not been fully investigated. However, as a minimum precaution, it should be considered harmful. Precautions should be taken and procedures adopted to prevent exposure.

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