Basic information Safety Supplier Related

VU-29

Basic information Safety Supplier Related

VU-29 Basic information

Product Name:
VU-29
Synonyms:
  • VU-29
  • BenzaMide, N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitro-
  • N-(1,3-Diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide
  • N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide
  • mGluR,hippocampal,inhibit,rat,LTP,VU29,potentiator,VU-29,allosteric,Metabotropic glutamate receptors,Inhibitor,LTD
  • VU-29/VU29
  • VU-29, 10 mM in DMSO
CAS:
890764-36-0
MF:
C22H16N4O3
MW:
384.39
Mol File:
890764-36-0.mol
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VU-29 Chemical Properties

Melting point:
221-223℃
Boiling point:
545.0±45.0 °C(Predicted)
Density 
1.30
storage temp. 
Store at RT
solubility 
Soluble to 100 mM in DMSO
form 
Powder
pka
11.17±0.70(Predicted)
color 
Light yellow to yellow
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VU-29 Usage And Synthesis

Uses

DPAP is a potent, postive allosteric, potentiator at mGluR-5.

in vivo

VU-29 (500 nM) potentiates DHPG induced increases in phosphoinositide (PI) hydrolysis in rat hippocampal slices. VU-29 potentiates threshold TBS-induced long term potentiation (LTP) in rat hippocampal CA1 region. VU-29 (1 μM) potentiates chemically induced mGluR-long term depression (LTD) in area CA1 of the rat hippocampus. VU-29 (1 μM) potentiates stimulus-induced NMDA receptor-independent LTD[1].

IC 50

rat mGluR5: 9 nM (EC50); rat mGluR1: 557 nM (EC50); rat mGluR2: 1.5 μM (EC50); hmGluR4: 154 nM (EC50); rat mGluR5: 224 nM (Ki)

VU-29Supplier

EMMX Biotechnology LLC
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888-539-0666
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info@emmx.com
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
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3008007409@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
Email
klq@cw-bio.com
ShangHai Biochempartner Co.,Ltd
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17754423994 17754423994
Email
2853530910@QQ.com
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VU-29(890764-36-0)Related Product Information