1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[carboxy(polyethylene glycol)-2000] (aMMoniuM salt) Chemical Properties

solubility 

Ethanol: Sparingly soluble: 1-10 mg/ml

InChIKey

MFOLYTNLQCGGBD-UHFFFAOYSA-N

SMILES

C(COC(=O)CCCCCCCCCCCCCCCCC)(OC(=O)CCCCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)O{-}CC{+n}OCC(=O)O.N

1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[carboxy(polyethylene glycol)-2000] (aMMoniuM salt) Usage And Synthesis

Description

DSPE-PEG-CH2COOH, MW 2,000 is a PEG polymer with DSPE and carboxylic acid end groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The -COOH group can react with primary amines in the presence of activator, such as EDC or HATU, to form a stable amide bond.

Uses

DSPE-PEG-Carboxylic Acid is a phospholipid PEG conjugate. DSPE-PEG-Carboxylic Acid can be widely used in the delivery of targeted agents and genes[1].

References

[1] Su H, et, al. A brightly red emissive AIEgen and its antibody conjugated nanoparticles for cancer cell targeting imaging. Materials Chemistry Frontiers. Issue 10, 2022.
[2] XUEMING LI . Targeted delivery of doxorubicin using stealth liposomes modified with transferrin[J]. International Journal of Pharmaceutics, 2009, 373 1: Pages 116-123. DOI: 10.1016/j.ijpharm.2009.01.023
[3] LINGWEI MENG . Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol[J]. International Journal of Pharmaceutics, 2019, 567: Article 118485. DOI: 10.1016/j.ijpharm.2019.118485

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