4-Ethylresorcinol Chemical Properties

Melting point:

95-98 °C (lit.)

Boiling point:

155 °C / 10mmHg

Density 

1.0742 (rough estimate)

refractive index 

1.5231 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Solubility in methanol; almost transparency. Soluble in alcohol.

form 

Crystalline Powder

pka

10.06±0.10(Predicted)

color 

Slightly beige

BRN 

1238231

InChIKey

VGMJYYDKPUPTID-UHFFFAOYSA-N

LogP

1.731 (est)

CAS DataBase Reference

2896-60-8(CAS DataBase Reference)

NIST Chemistry Reference

1,3-Benzenediol, 4-ethyl-(2896-60-8)

EPA Substance Registry System

4-Ethylresorcinol (2896-60-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

TSCA 

Yes

HS Code 

29072100

MSDS

• Language:English Provider:2,4-Dihydroxy-1-ethylbenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Ethylresorcinol Usage And Synthesis

Description

4-Ethylresorcinol is a derivative of resorcinol, which acts as a substrate for tyrosinase. 4-Ethylresorcinol has hypopigmentation effects.4-Ethylresorcinol attenuates the mRNA and protein expression of tyrosinase-related protein (TRP)-2, and has an antioxidant effect through the inhibition of lipid peroxidation. 4-Ethylresorcinol is a derivative of resorcinol, which acts as a substrate for tyrosinase. 4-Ethylresorcinol is a derivative of resorcinol.

Chemical Properties

slightly beige crystalline powder

Uses

It is employed as an active pharmaceutical intermediate.

Definition

ChEBI: 4-Ethylresorcinol is a member of resorcinols.

Synthesis Reference(s)

Synthetic Communications, 15, p. 1315, 1985 DOI: 10.1080/00397918508077280

Synthesis

The synthesis of 4-Ethylresorcinol is as follows:
In a three necked round bottom flask (equipped with a condensor, additional funnel and mechanical stirrer) was added 15.2 g of a combination of Raney Nickel and Ni supported on silica. (50: 50). 100 ml of a mixture of 50: 50 ethanol: water was added and the reaction was heated at reflux conditions. 15.2 g of 2,4-dihydroxy acetophenone in 100 ml of water: ethanol and 10 ml of acetic acid was placed in the additional funnel and slowly added to the mixture (dropwise). The reaction was filtered through a milipore filter to give a pale yellow solution. Concentration of this solution in vacuo gave a solid. This solid was crystalized from 1,2-dichloroethane to give 4-ethyl resorcinol in 80% isolated yield. 

4-Ethylresorcinol (2896-60-8)Related Product Information

• 4-Hydroxybenzoic acid
• 4-Chlororesorcinol
• p-(2-Methoxyethyl) phenol
• 4-tert-Butylcatechol
• Triclosan
• Resorcinol
• Ethyl cellulose
• Solvent Red 43
• 1,3-Dimethoxybenzene
• Methylparaben
• Catechol
• 2-Methylresorcinol
• Ethyl acrylate
• Ethanol
• Ethyl acetate
• 3-Diethylaminophenol
• Ethylbenzene
• 2-Hydroxyphenylacetic acid