Cholesteryl hemisuccinate Chemical Properties

Melting point:

178 °C

Boiling point:

586.0±43.0 °C(Predicted)

Density 

1.06±0.1 g/cm3(Predicted)

refractive index 

-34 ° (C=2, CHCl3)

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)

form 

Solid

pka

4.40±0.17(Predicted)

color 

White to Off-White

InChIKey

WLNARFZDISHUGS-BLYFUZNHSA-N

LogP

10.708 (est)

CAS DataBase Reference

1510-21-0(CAS DataBase Reference)

Safety Information

WGK Germany 

3

HS Code 

29171900

Cholesteryl hemisuccinate Usage And Synthesis

Description

Cholesteryl hemisuccinate is a cholesterol ester with anticancer activity. It inhibits the growth of murine C1498 myeloid and L1210 lymphocytic leukemia cells when used at concentrations of 50 and 150 μM, respectively. Cholesteryl hemisuccinate acts as an ionizable anionic detergent and is commonly used to stabilize unilamellar vesicles and liposomes. It has also been used as an emulsifying agent in various vesicular drug delivery systems for anticancer drugs, antibiotics, and oligonucleotides and to solubilize various proteins including chemokine receptor 1 as well as erythrocyte ghosts.

Uses

Cholesteryl Hemisuccinate is an oxidation product of polyunsaturated fatty acid of cholesterol that alters lysosome structure and functions and induces proinflammatory cytokine production in macrophages.

Definition

ChEBI: Cholesteryl hemisuccinate is a dicarboxylic acid monoester resulting from the formal condensation of the hydroxy group of cholesterol with one of the carboxy groups of succinic acid. A detergent that is often used to replace cholesterol in protein crystallography, biochemical studies of proteins, and pharmacology. It has a role as a detergent. It is a cholestane ester, a dicarboxylic acid monoester and a hemisuccinate. It is functionally related to a cholesterol.

General Description

Cholesteryl hemisuccinate (CHEMS) is an acidic cholesterol ester.

Biochem/physiol Actions

CHEMS can help to maintain the stability of dioleoylphosphatidylethanolamine (DOPE). This amphipathic lipid is used in mixtures with dioleoylphosphatidylethanolamine (DOPE) to form ′pH sensitive′ fusogenic vesicles. It can control cell growth.

Cholesteryl hemisuccinate(1510-21-0)Related Product Information

• 6alpha-Methylprednisolone sodium succinate
• Disodium succinate
• Hydrogen
• Hydrogen Sulfide
• iron succinate
• CHLOROPHOSPHONAZO III
• Dimethyl succinate
• Succinic acid
• Cholesteryl oleate
• HYDROGEN CYANIDE
• Hydrogen peroxide
• Cholesterol
• (-)-Cholesterol sulfo-NHS succinate
• CHOLESTERYL HEMISUCCINATE F & D VERSION&,CHOLESTERYL HEMISUCCINATE TRIS,CHOLESTERYL HEMISUCCINATE TRIS SALT,CHOLESTERYL HYDROGEN SUCCINATE TRIS SALT
• (-)-Cholesterol NHS succinate
• hydrogen fluoride
• 5-CHOLESTENE
• Cholesteryl hemisuccinate