2-Chloro-N-methylacetamide
2-Chloro-N-methylacetamide Basic information
- Product Name:
- 2-Chloro-N-methylacetamide
- Synonyms:
-
- OTAVA-BB BB7020410071
- N-METHYL-2-CHLOROACETAMIDE
- chloroacetylmethylamide
- 2-CHLORO-N-METHYLACETAMIDE
- 2-chloro-n-methyl-acetamid
- Acetamide, 2-chloro-N-methyl-
- alpha-Chloro-N-methylacetamide
- N-Methylchloroacetamide
- CAS:
- 96-30-0
- MF:
- C3H6ClNO
- MW:
- 107.54
- EINECS:
- 202-497-1
- Product Categories:
-
- Acids and Derivatives
- Mol File:
- 96-30-0.mol
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2-Chloro-N-methylacetamide Chemical Properties
- Melting point:
- 38-40°C
- Boiling point:
- 112-115°C 20mm
- Density
- 1.127±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.38±0.46(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C3H6ClNO/c1-5-3(6)2-4/h2H2,1H3,(H,5,6)
- InChIKey
- HOZLOOPIXHWKCI-UHFFFAOYSA-N
- SMILES
- C(NC)(=O)CCl
- CAS DataBase Reference
- 96-30-0(CAS DataBase Reference)
- NIST Chemistry Reference
- ClCON(CH3)2(96-30-0)
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Safety Information
- Risk Statements
- 36/37/38-43-22
- Safety Statements
- 26-36/37/39-36/37-24
- RTECS
- AB5775000
- HazardClass
- IRRITANT
- HS Code
- 29241990
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2-Chloro-N-methylacetamide Usage And Synthesis
Uses
2-Chloro-N-methylacetamide is an intermediate used to prepare piperidinylamino pyrrolopyrimidines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.
Synthesis
To methylamine hydrochloride (896 mg, 13.3 mmol) and Na2C03 (5630 mg, 53 mmol) in water (26 mL) was added 2-chloroacetyl chloride (1500 mg, 13.3 mmol). The mixture was stirred at r.t. for lh and extracted with EtOAc (2x). The combined organic layers were dried over Na2S04 and concentrated to provide 2-Chloro-N-methylacetamide (1200 mg, 84%).
2-Chloro-N-methylacetamide Preparation Products And Raw materials
Preparation Products
2-Chloro-N-methylacetamideSupplier
Creasyn Finechem(Tianjin) Co., Ltd.
- Tel
- 022-83946278 13820503911
- sales@creasyn.com
Alfa Aesar
- Tel
- 400-6106006
- saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
- Tel
- 021-67121386
- Sales-CN@TCIchemicals.com
Energy Chemical
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
Wuhan Chemwish Technology Co., Ltd
- Tel
- 86-027-67849912
- sales@chemwish.com
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2-Chloro-N-methylacetamide(96-30-0)Related Product Information
- tert-Butyldimethylsilyl chloride
- Epichlorohydrin
- N,N-Dimethylacetamide
- N-(HYDROXYMETHYL)ACETAMIDE
- Chloroacetamide
- N-Methylacetamide
- 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
- 3,5-DICHLORO-2-PYRIDONE
- 5-Chlorouracil
- N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
- 2-Chloro-N-(2,6-dimethylphenyl)acetamide
- N-(CHLOROACETYL)-2-(TRIFLUOROMETHYL)ANILINE
- 2,2,2-TRICHLORO-3'-TRIFLUOROMETHYLACETANILIDE
- Chloromethyl methyl ether
- Chloroacetic acid
- N-(CHLOROACETYL)-4-FLUOROANILINE
- Difluorochloromethane
- 2-Chloro-N,N-diethylacetamide