4-(Trifluoromethoxy)benzyl bromide Chemical Properties

Melting point:

22-24°C

Boiling point:

82-84 °C10 mm Hg(lit.)

Density 

1.594 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.48(lit.)

Flash point:

202 °F

storage temp. 

Refrigerated.

solubility 

soluble in Chloroform, Methanol

form 

Liquid or Low Melting Solid

Specific Gravity

1.594

color 

Clear faintly yellow

Sensitive 

Lachrymatory

BRN 

2521451

CAS DataBase Reference

50824-05-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-27-28-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

Hazard Note 

Corrosive/Lachrymatory

HazardClass 

8

PackingGroup 

III

HS Code 

29093090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-(Trifluoromethoxy)benzyl bromide Usage And Synthesis

Uses

4-Trifluoromethoxybenzyl Bromide is a useful synthetic intermediate. It is used to prepare (nitro)[(trifluoromethoxy)benzyloxy]dihydroimidazo[2,1-b][1,3]oxazines with antitubercular activities. It is also used to synthesize tetrahydronaphthalenols with anti-allergic activities.

Chemical Properties

Colorless to light yellow liqui

Uses

4-(Trifluoromethoxy)benzyl bromide may be used in the synthesis of bioreductive drug, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

General Description

Polymerizations of 4-(trifluoromethoxy)benzyl bromide, via Friedel-Crafts polymerization using aluminum chloride as a catalyst has been reported.

4-(Trifluoromethoxy)benzyl bromide(50824-05-0)Related Product Information

• 4-(Trifluoromethoxy)aniline
• 4-Fluorobenzyl chloride
• (Trifluoromethoxy)benzene
• Ethyl bromodifluoroacetate
• alpha-Chloro-o-fluorotoluene
• Ethidium bromide
• Sodium bromate
• 4-Methoxybenzyl bromide
• 4-Methoxybenzylchloride
• BRETYLIUM TOSYLATE
• Benzyl alcohol
• Rocuronium bromide
• Allyl bromide
• Benzyl bromide
• 3-FLUORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE
• 3-CHLORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE,3-CHLORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE, 98%(MIN,GC)
• 2,6-DICHLORO-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE
• 2-METHOXY-4-(TRIFLUOROMETHOXY)BENZYL BROMIDE