ACA Chemical Properties

Melting point:

172-174℃

Boiling point:

563.1±50.0 °C(Predicted)

Density 

1.178±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly, Heated), Methanol (Slightly)

pka

3.49±0.36(Predicted)

form 

White solid.

color 

White to Off-White

Safety Information

HazardClass 

9

ACA Usage And Synthesis

Uses

N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.

Definition

ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide.

References

harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6.

ACA(110683-10-8)Related Product Information

• Inositol
• alpha-Amylcinnamaldehyde
• H-6-Aca-OH~epsilon-Aminocaproic acid~6-Aminohexanoic acid~EACA,h-6-aca-oh
• Boc-6-AMinocaproic acid
• 7-TMCA
• Hydroxymethyl-7-ACA
• N-Benzyloxycarbonyl-6-aminohexanoic acid
• 7-ACA-3-MTT-7-MO,7-ACA-3-MTT-7-MO / 7-MAC
• ACA
• 7-ACA
• 7-Aca-3-SmtC10H12N6O6S3,7-aca-3-smt
• FMOC-6-ACA-OH
• ECPP-ACA
• Glutaryl-7-ACA acylase
• ACA
• 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID
• ACA
• AKOS BBS-00007306