2-Hydroxy-4-(trifluoromethyl)quinoline Chemical Properties

Melting point:

>240°C

Boiling point:

284 ºC

Density 

1.391

Flash point:

126 ºC

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

color 

White

InChI

InChI=1S/C10H6F3NO/c11-10(12,13)7-5-9(15)14-8-4-2-1-3-6(7)8/h1-5H,(H,14,15)

InChIKey

UUROBWTVZZNDFD-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2)C(C(F)(F)F)=CC1=O

CAS DataBase Reference

25199-84-2

Safety Information

Safety Statements 

24/25

HS Code 

29339900

2-Hydroxy-4-(trifluoromethyl)quinoline Usage And Synthesis

Chemical Properties

White solid

Synthesis

4-Trifluoromethylquinolin-2(1H)-one was prepared by reacting aniline and ethyl-4,4,4-trifluoroacetoacetate stirred in toluene.
Experimental Procedure: In a 1 L round flask fitted with a reflux condenser a mixture of 25.60 g aniline, 50.0 g ethyl-4,4,4-trifluoroacetoacetate 300 ml toluene was heated to reflux in an oil bath at 130 °C. After 20 min 3 ml water was added and the mixture was heated at reflux for another 24 h. the reaction mixture was cooled to room temperature and concentrated under reduced pressure. A round flask with 200 mL H2SO4 was heated to 80°C and the crude oil from the step before was added in portions to the H2SO4 keeping the internal temperature below 90°C, total addition time was approximately 40 min. After addition was complete, the mixture was stirred at 80°C for 1 h, cooled and poured onto 400 g crushed ice. The resulting solids were filtered, washed with water, and dried under vacuum at 40°C to give 33.0 g (50%) product (2-Hydroxy-4-(trifluoromethyl)quinoline) as a colorless solid.

2-Hydroxy-4-(trifluoromethyl)quinoline(25199-84-2)Related Product Information

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• 4-Aminobenzotrifluoride
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• CHLOROPHOSPHONAZO III
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• 4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid 85%,4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylicacid85%
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• 4-Hydroxy-2-(trifluoromethyl)quinoline ,98%,4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE,4-Hydroxy-2-(trifluoromethyl)quinoline 95+%
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• 5,7-DICHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE
• 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ACID