3-Bromo-2-fluoropyridine Chemical Properties

Boiling point:

76°C

Density 

1.729

refractive index 

1.5370-1.5410

Flash point:

54℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

pka

-2.79±0.10(Predicted)

color 

Colorless to Light yellow

CAS DataBase Reference

36178-05-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

RIDADR 

2810

HazardClass 

6.1

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

29333990

3-Bromo-2-fluoropyridine Usage And Synthesis

Chemical Properties

Light yellow liquid

Synthesis

GENERAL METHOD: 2,3-Dichloropyridine (1.00 g, 6.76 mmol) was dissolved in DMSO (33.8 mL) at room temperature, followed by the addition of CsF (2.053 g, 13.51 mmol). The reaction mixture was stirred at 110 °C for 20 h in air. Upon completion of the reaction, the reaction mixture was quenched with ice water and extracted with EtOAc. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous Na2SO4 and subsequently concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel as stationary phase and EtOAc in hexane as eluent) afforded 3-chloro-2-fluoropyridine (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. Compounds 3B'-8B' were prepared by a method similar to the synthetic procedure described above for 2B'.

References

[1] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046

3-Bromo-2-fluoropyridine(36178-05-9)Related Product Information

• 3-Aminopyridine
• 2-Chloro-3-cyanopyridine
• 1-Hexadecylpyridinium bromide
• 3-Bromoanisole
• 3-Pyridyl bromide
• 3-Hydroxypyridine
• Ethyl bromodifluoroacetate
• 2-Fluoro-3-iodopyridine
• 2-Fluoropyridine
• Flupirtine
• 2,3,5-Collidine
• 6-BENZYL-5,7-DIOXO-OCTAHYDROPYRROLO[3,4-B] PYRIDINE
• 2-Hydroxy-4-methyl-5-nitropyridine
• 4-chloropyridine
• Bromine
• 3-BROMO-2-FLUORO-6-PICOLINE
• 3-BROMO-5-CHLORO-2-FLUOROPYRIDINE
• 3,4-DIBROMO-2-FLUOROPYRIDINE