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Ketoprofen lysinate

Basic information Safety Supplier Related

Ketoprofen lysinate Basic information

Product Name:
Ketoprofen lysinate
Synonyms:
  • 2-(3-benzoylphenyl)propanoic acid: (2R)-2,6-diaminohexanoic acid
  • ketoprofen lysine
  • 2-(3-Benzoylphenyl)propanoic acid lysine salt
  • Ketoprofen lysine salt
  • Lysyl-ketoprofen
  • Ketoprofen lysinate
  • Lysine salt
  • Ketoprofen lysinate USP/EP/BP
CAS:
57469-78-0
MF:
C22H28N2O5
MW:
400.47
Mol File:
57469-78-0.mol
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Ketoprofen lysinate Chemical Properties

Melting point:
145-149 °C
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Ketoprofen lysinate Usage And Synthesis

Uses

Ketoprofen Lysinate is a non-steroidal anti-inflammatory drug used in the symptomatic treatment of some chronic inflammatory diseases. An anti-inflammatory agent.

in vivo

Ketoprofen lysinate (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%)[2]. Ketoprofen lysinate (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS[3].

Animal Model:HFD-induced obese C57BL/6 mice[2]
Dosage:10 mg/kg
Administration:Oral administration, three times a week for 10 weeks
Result:Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin.
Animal Model:LPS (0.2 μg/mL)-treated dairy cows [3]
Dosage:50 mg/kg
Administration:Injection (Milk samples were taken every 30 min until 6 and 9 h)
Result:Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk.

IC 50

COX-1: 2 nM (IC50); COX-2: 26 nM (IC50)

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