Guanosine-5'-diphosphate disodium salt Chemical Properties

Melting point:

>280°C (dec.)

storage temp. 

-20°C

solubility 

H₂O: 50 mg/mL, clear, colorless

form 

Powder

color 

White

biological source

Porcine brain
microbial (Corynebacterium sp)
synthetic

Water Solubility 

Soluble in water

Stability:

Hygroscopic

InChIKey

PVMPTWQLNDHIEV-NGPBCCOENA-N

SMILES

O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(NC(N)=NC1=2)=O)O.[NaH] |&1:1,2,3,15,r|

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36/37/39-27-26

WGK Germany 

3

F 

3-10-21

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

Guanosine-5'-diphosphate disodium salt Usage And Synthesis

Uses

Guanosine 5'-diphosphate disodium salt is a useful research chemical.

Uses

Guanosine-5'-diphosphate disodium salt is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors. It is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.

General Description

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

Biochem/physiol Actions

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).

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