Basic information Uses Safety Supplier Related

Guanosine-5'-diphosphate disodium salt

Basic information Uses Safety Supplier Related

Guanosine-5'-diphosphate disodium salt Basic information

Product Name:
Guanosine-5'-diphosphate disodium salt
Synonyms:
  • GUANOSINE-5'-DIPHOSPHATE MONOSODIUM SALT
  • GUANOSINE-5'-DIPHOSPHORIC ACID, DISODIUM
  • GDP, NA2H
  • GDP
  • 5'-GDP-Na
  • guanosine 5-(disodium hydrogen pyrophosphate)
  • GUANOSINE 5'-DIPHOSPHATE DISODIUM SALT 85+%
  • Guanosine 5-(trihydrogen diphosphate), disodium salt
CAS:
7415-69-2
MF:
C10H16N5NaO11P2
MW:
467.2
EINECS:
231-026-2
Product Categories:
  • Material
  • Pharmaceutical
  • 7415-69-2
Mol File:
7415-69-2.mol
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Guanosine-5'-diphosphate disodium salt Chemical Properties

Melting point:
>280°C (dec.)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
Powder
color 
White
biological source
Porcine brain
microbial (Corynebacterium sp)
synthetic
Water Solubility 
Soluble in water
Stability:
Hygroscopic
InChIKey
PVMPTWQLNDHIEV-NGPBCCOENA-N
SMILES
O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(NC(N)=NC1=2)=O)O.[NaH] |&1:1,2,3,15,r|
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
F 
3-10-21
HS Code 
29349990

MSDS

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Guanosine-5'-diphosphate disodium salt Usage And Synthesis

Uses

Guanosine 5'-diphosphate disodium salt is a useful research chemical.

Uses

Guanosine-5'-diphosphate disodium salt is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors. It is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.

General Description

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

Biochem/physiol Actions

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).

in vivo

Guanosine 5'-diphosphate disodium salt (30 mg/kg, i.p., a single dose for 24 h) combined with FeSO4 (2 mg/kg, i.p., a single dose for 24 h) suppresses the iron storage ferritin level, thus preventing Hepcidin (HY-P70400)-induced internalization of FPN with increased iron absorption in normal mice[2].
Guanosine 5'-diphosphate disodium salt (30 mL/kg, i.p., three times a week for two weeks) can improve turpentine-induced inflammatory anemia in mice[1].

Animal Model:Male BALB/c mice[2].
Dosage:30 mL/kg
Administration:Intraperitoneal injection (i.p.)
Result:Increased hemoglobin levels and serum iron levels in the long-term dosing model.
Decreased Hamp mRNA expression, and spleen iron content was reduced by 46% in the short-term dosing model.

IC 50

Human Endogenous Metabolite

Guanosine-5'-diphosphate disodium saltSupplier

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