4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide Basic information
- Product Name:
- 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
- Synonyms:
-
- 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
- PF 429242
- o)Meth (2-MetR)-4-((diethylaMinyl)-Nhoxyphenethyl)-N-(pyrrolidin-3-yl)benzaMide
- 4-((diethylaMino)Methyl)-N-(2-Methoxyphenethyl)-N-(pyrrolidin-3-yl)benzaMide
- PF-429242 dihydrochloride
- 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-benzamide dihydrochloride
- Benzamide, 4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-
- -4-((Diethylamino)
- CAS:
- 947303-87-9
- MF:
- C25H35N3O2
- MW:
- 409.57
- Mol File:
- 947303-87-9.mol
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide Chemical Properties
- Boiling point:
- 562.2±50.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- H2O: soluble15mg/mL, clear
- form
- powder
- pka
- 9.47±0.10(Predicted)
- color
- white to beige
- InChIKey
- XKPJTOHUPQWSOJ-HSZRJFAPSA-N
Safety Information
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-50
- Safety Statements
- 26-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide Usage And Synthesis
Uses
PF 429242 is a novel subtilisin kexin isozyme-1/site-1 (SKI-1/S1P) protease inhibitor. PF 429242 is a sterol regulatory element-binding protein1 (SREBP1) inhibitor and has been shown to decrease pancreatic cancer cell viability and proliferation.
Biochem/physiol Actions
PF-429242 is a potent inhibitor of S1P (cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) that reduces expression levels of hepatic SREBP target genes and lower rates of cholesterol and fatty acid synthesis in mice. PF-429242 is a potent antiviral agent against prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV in cultured cells. PF-429242 efficiently prevented the processing of GPC from the LCMV and LASV. PF-429242 is expected to be active against CCHFV.
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamideSupplier
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