Basic information Safety Supplier Related

PF-06281355

Basic information Safety Supplier Related

PF-06281355 Basic information

Product Name:
PF-06281355
Synonyms:
  • PF-06281355
  • PF-1355
  • PF-06281355 (Free base)
  • 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
  • 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide
  • PF06281355;PF1355;PF 1355;PF-06281355;PF 06281355
  • 1(2H)-Pyrimidineacetamide, 6-(2,5-dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-
  • PF-06281355 >=98% (HPLC)
CAS:
1435467-38-1
MF:
C14H15N3O4S
MW:
321.35
Mol File:
1435467-38-1.mol
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PF-06281355 Chemical Properties

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10mg/mL; DMF:PBS (pH 7.2) (1:1): 0.5mg/mL; DMSO: 10mg/mL; Ethanol: 5mg/mL
form 
A crystalline solid
pka
6.93±0.40(Predicted)
color 
White to off-white
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PF-06281355 Usage And Synthesis

Uses

PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.

Biological Activity

PF-06281355 (PF-1355) is an orally available, selective and potent mechanism based inhibitor of the myeloperoxidase (MPO) th at reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. PF-06281355 suppresses albuminuria and chronic renal dysfunction in model of anti-Glomerular Basement Membrane (GBM) disease.

in vivo

Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Goodpasture disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment[1].

storage

Store at RT

References

[1] Zheng W, et al. PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015 May;353(2):288-98 DOI:10.1124/jpet.114.221788

PF-06281355Supplier

Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-846993838003-8003 18013301590
Email
njduly@126.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Email
klq@cw-bio.com
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Email
2853530910@QQ.com
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