PF-6260933
PF-6260933 Basic information
- Product Name:
- PF-6260933
- Synonyms:
-
- PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933
- PF-6260933
- PF06260933
- [3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-
- inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933
- 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine
- CAS:
- 1811510-56-1
- MF:
- C16H13ClN4
- MW:
- 296.75
- Mol File:
- 1811510-56-1.mol
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PF-6260933 Chemical Properties
- Boiling point:
- 483.8±40.0 °C(Predicted)
- Density
- 1.330±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
- form
- A solid
- pka
- 5.04±0.13(Predicted)
- color
- White to off-white
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PF-6260933 Usage And Synthesis
Biological Activity
PF-6260933 is a MAP4K4 inhibitor with IC50 of 3.7 nM and good kinome selectivity.
in vitro
PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.
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in vivo
In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.
p>
target
| Target | Value |
| MAP4K4 () | 3.7 nM |
PF-6260933Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
- Tel
- 21-31433387 15618786686
- sales@rechemscience.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Shanghai SuperLan Chemcial Technique Centre
- Tel
- 021-2022843681 15618226720
- lucy@atkchemical.com
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