Basic information Safety Supplier Related

PF-6260933

Basic information Safety Supplier Related

PF-6260933 Basic information

Product Name:
PF-6260933
Synonyms:
  • PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933
  • PF-6260933
  • PF06260933
  • [3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-
  • inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933
  • 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine
CAS:
1811510-56-1
MF:
C16H13ClN4
MW:
296.75
Mol File:
1811510-56-1.mol
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PF-6260933 Chemical Properties

Boiling point:
483.8±40.0 °C(Predicted)
Density 
1.330±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form 
A solid
pka
5.04±0.13(Predicted)
color 
White to off-white
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Safety Information

HS Code 
2933998090
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PF-6260933 Usage And Synthesis

Biological Activity

PF-6260933 is a MAP4K4 inhibitor with IC50 of 3.7 nM and good kinome selectivity.

in vitro

PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.

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in vivo

In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.

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target

TargetValue
MAP4K4
()
3.7 nM

PF-6260933Supplier

Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266
ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
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21-31433387 15618786686
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sales@rechemscience.com
Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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info@SuperLan-chem.com
Shanghai SuperLan Chemcial Technique Centre
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021-2022843681 15618226720
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chaolaichem@foxmail.com