p-Trifluoromethoxy phenol Chemical Properties

Melting point:

17-18°C

Boiling point:

92 °C25 mm Hg(lit.)

Density 

1.375 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.447(lit.)

Flash point:

187 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform, Methanol

form 

Liquid

pka

9.30±0.13(Predicted)

Specific Gravity

1.375

color 

Clear brown

BRN 

1945934

InChIKey

NWVVVBRKAWDGAB-UHFFFAOYSA-N

CAS DataBase Reference

828-27-3(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 4-(trifluoromethoxy)-(828-27-3)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-27-36/37/39

RIDADR 

2927

WGK Germany 

2

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29095090

MSDS

• Language:English Provider:p-Trifluoromethoxy phenol
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p-Trifluoromethoxy phenol Usage And Synthesis

Uses

4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.

Chemical Properties

clear brown liquid

Uses

4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.

Uses

4-(Trifluoromethoxy)phenol was employed in the catalytic enantioselective synthesis of esters.

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

Journal of Medicinal Chemistry, 25, p. 1097, 1982 DOI: 10.1021/jm00351a018

p-Trifluoromethoxy phenol(828-27-3)Related Product Information

• Nonylphenol
• 4-(Trifluoromethoxy)aniline
• p-(2-Methoxyethyl) phenol
• 4-Aminophenol
• 4-(Trifluoromethoxy)benzaldehyde
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• 4'-Methoxyacetophenone
• 4-Methoxybenzoic acid
• (Trifluoromethoxy)benzene
• Phenol
• Phenol Red
• 4-(Trifluoromethylthio)phenol
• 2-Fluorophenol
• Guaiacol
• 4'-(Trifluoromethoxy)acetophenone
• 4-Fluorophenol
• Anisole
• 4-(Trifluoromethoxy)chlorobenzene