2-Methoxy-5-(trifluoromethyl)aniline Chemical Properties

Melting point:

58-60 °C (lit.)

Boiling point:

230.1±40.0 °C(Predicted)

Density 

1.2645 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.31±0.10(Predicted)

form 

Crystalline Powder

color 

Beige-gray to brown

BRN 

2835713

InChI

InChI=1S/C8H8F3NO/c1-13-7-3-2-5(4-6(7)12)8(9,10)11/h2-4H,12H2,1H3

InChIKey

RKUSRLUGUVDNKP-UHFFFAOYSA-N

SMILES

C1(N)=CC(C(F)(F)F)=CC=C1OC

CAS DataBase Reference

349-65-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36-36/37/39

RIDADR 

UN2811

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29222990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Methoxy-5-(trifluoromethyl)aniline Usage And Synthesis

Chemical Properties

Beige-greyish to brownish crystalline powder

Uses

2-Methoxy-5-(trifluoromethyl)aniline may be used in chemical synthesis.

Definition

ChEBI: 2-Methoxy-5-(trifluoromethyl)aniline is a member of (trifluoromethyl)benzenes.

Synthesis

Example 51 General procedure for the synthesis of 4-(8-methoxy-5-(trifluoromethyl)quinazolin-2-ylamino)phenyl)(morpholino)methanone (Compound 500) PP028218.0002: Step 1. Prepare a mixture of 2-methoxy-5-(trifluoromethyl)aniline A. A methanolic solution of 4-methoxy-3-nitrobenzotrifluoride and 10% Pd/C catalyst (10% loading) was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst, and the filtrate was concentrated under reduced pressure and dried under vacuum to afford the target product 2-methoxy-5-(trifluoromethyl)aniline A in 99% yield as an off-white solid.ESI-MS m/z: 192.1 (MH+).

References

[1] Synthesis, 2006, # 19, p. 3316 - 3340
[2] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 363-364
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 3011,3012
[4] Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1955, vol. 28, p. 969,972
[5] Chem.Abstr., 1956, p. 4880

2-Methoxy-5-(trifluoromethyl)aniline(349-65-5)Related Product Information

• 2-Methoxy-5-methylaniline
• 2,3-DIAMINOTOLUENE
• 2-(Trifluoromethoxy)aniline
• 3-(Trifluoromethyl)benzaldehyde
• Dinitramine
• Aniline
• o-Anisidine
• N,N-Dimethylaniline
• ALTRENOGEST
• 2-Methylbenzotrifluoride
• N-Methylaniline
• Tosufloxacin tosylate
• 2-Methyl-4-methoxybenzenamine
• 2-Aminobenzotrifluoride
• Glycine
• (Trifluoromethoxy)benzene
• 2-Methoxyethanol
• Betaine