H2N-PEG3-CH2COOtBu Chemical Properties

Boiling point:

343.4±27.0 °C(Predicted)

Density 

1.041±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

8.74±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C12H25NO5/c1-12(2,3)18-11(14)10-17-9-8-16-7-6-15-5-4-13/h4-10,13H2,1-3H3

InChIKey

OTTHWLFOQWLZKB-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)COCCOCCOCCN

H2N-PEG3-CH2COOtBu Usage And Synthesis

Description

Amino-PEG3-CH2CO2-t-butyl ester is a PEG molecule containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group (t-Boc) can be deprotected under acidic conditions.

Uses

NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

H2N-PEG3-CH2COOtBu(189808-70-6)Related Product Information

• H2N-PEG2-CH2COOtBu
• 1-AMinooctaethylene Glycol
• TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA
• 1,14-Diazido-3,6,9,12-tetraoxatetradecane
• 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester
• 2-[2-(2-Azidoethoxy)ethoxy]ethanamine
• alpha, oMega-DisucciniMidyl hexaethylene glycol
• 2-(2-Azidoethoxy)ethanol
• H2N-PEG11-CH2CH2COOH
• N3-PEG3-tBu
• Acid-PEG3-mono-methyl ester
• Amino-PEG10-alcohol
• Azide-PEG4-Tos
• alpha-aMine-oMega-propionic acid decaethylene glycol
• H2N-PEG12-tBu
• Azido-PEG7-azide
• Amino-PEG9-acid
• H2N-PEG24-CH2CH2COOtBu