Basic information Safety Supplier Related

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

Basic information Safety Supplier Related

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Basic information

Product Name:
TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA
Synonyms:
  • [(+)-BIOTIN-PEG12-NHS ESTER]
  • H2N-PEG3-CH2CH2-t-butylester
  • tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate
  • Amino-PEG3-COOtBu
  • TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA
  • H2N-PEG3-tBu
  • H2N-PEG3-CH2CH2COOtBu
  • tert-Butyl 12-aMino-4,7,10-trioxa-dodec
CAS:
252881-74-6
MF:
C13H27NO5
MW:
277.36
Product Categories:
  • PEG-COOtBu
  • peg
Mol File:
252881-74-6.mol
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TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Chemical Properties

Boiling point:
358.5±27.0 °C(Predicted)
Density 
1.029±0.06 g/cm3(Predicted)
Flash point:
169.7 °C
storage temp. 
-20°C
form 
oil
pka
8.74±0.10(Predicted)
color 
Clear
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
10-34
HS Code 
2922500090
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TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Usage And Synthesis

Description

Amino-PEG3-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:

  • Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
  • Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
  • Synthesis of polycationic adamantane-based dendrons for cell imaging.
  • Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECASupplier

Shanghai Huici Pharmaceutical Technology Co., LTD Gold
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19372841038 19372841038
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lixing@pharmahuici.com
PharmaBlock Sciences (Nanjing),Inc.
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400-0255188 4000255188
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sales@pharmablock.com
BeiJing Hwrk Chemicals Limted
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0757-86329057 18934348241
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Energy Chemical
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021-021-58432009 400-005-6266
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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sales@accelachem.com