4-(Hydroxymethyl)benzoic acid
4-(Hydroxymethyl)benzoic acid Basic information
- Product Name:
- 4-(Hydroxymethyl)benzoic acid
- Synonyms:
-
- HMBA
- HMBA LINKER
- 4-CARBOXYBENZYL ALCOHOL
- 4-HYDROXYMETHYLBENZOIC ACID
- RARECHEM AL BO 1443
- HMBA LINKER,4-HYDROXYTHYLBENZOIC ACID
- Hydroxymethylbenzoicacid
- 4-Hydroxythylbenzoic acid
- CAS:
- 3006-96-0
- MF:
- C8H8O3
- MW:
- 152.15
- EINECS:
- 628-233-9
- Product Categories:
-
- Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
- Organic acids
- Linkers for Solid Phase Synthesis
- Combinatorial Chemistry
- Linkers
- Synthetic Organic Chemistry
- Biochemics
- Bifunctional CrosslinkersCarbonyl Compounds
- C8
- Carboxylic Acids
- Peptide Synthesis
- Mol File:
- 3006-96-0.mol
4-(Hydroxymethyl)benzoic acid Chemical Properties
- Melting point:
- 182-185 °C (lit.)
- Boiling point:
- 140-150 °C(Press: 9 Torr)
- Density
- 1.314±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- pka
- 4.16±0.10(Predicted)
- form
- Coarse Fibers
- color
- White
- BRN
- 2690023
- InChIKey
- WWYFPDXEIFBNKE-UHFFFAOYSA-N
- LogP
- 0.930
- CAS DataBase Reference
- 3006-96-0(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HS Code
- 29181990
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
4-(Hydroxymethyl)benzoic acid Usage And Synthesis
Chemical Properties
Off-white solid
Uses
This linkage reagent for SPPS is essentially acid stable. It is useful in combination with Fmoc-amino acids. Its peptide esters are usually cleaved by basic or nucleophilic reagents, especially by ammonia in the preparation of peptide amides.
Uses
4-(Hydroxymethyl)benzoic Acid (Eprosartan USP Related Compound E) is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.
Uses
4-(Hydroxymethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive age nt.
Synthesis Reference(s)
Journal of the American Chemical Society, 107, p. 1365, 1985 DOI: 10.1021/ja00291a042
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4-(Hydroxymethyl)benzoic acid(3006-96-0)Related Product Information
- Tris(hydroxymethyl)nitromethane
- 2-(Trifluoromethyl)benzoic acid
- p-Toluic acid
- 4-Bromomethylbenzoic acid
- 4-(Aminomethyl)benzoic acid
- o-Toluic acid
- m-Toluic acid
- 4-(Chloromethyl)benzoic acid
- 4-(Hydroxymethyl)phenoxyacetic acid
- EPROSARTAN
- Epalrestat iMpurity
- α-Methylcinnamaldehyde
- ethyl 2-((E)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetate
- (2-CHLORO-ACETYLAMINO)-ACETIC ACID METHYL ESTER
- 3-(2-THIENYL)PROPIONIC ACID
- Eprosartan related coMpound C
- 3-Thiazolidineacetic acid, 4-oxo-2-thioxo-, methyl ester
- Rhodanine-3-acetic acid