4-(Hydroxymethyl)benzoic acid Chemical Properties

Melting point:

182-185 °C (lit.)

Boiling point:

140-150 °C(Press: 9 Torr)

Density 

1.314±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO, Methanol

pka

4.16±0.10(Predicted)

form 

Coarse Fibers

color 

White

BRN 

2690023

InChIKey

WWYFPDXEIFBNKE-UHFFFAOYSA-N

LogP

0.930

CAS DataBase Reference

3006-96-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HS Code 

29181990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-(Hydroxymethyl)benzoic acid Usage And Synthesis

Chemical Properties

Off-white solid

Uses

This linkage reagent for SPPS is essentially acid stable. It is useful in combination with Fmoc-amino acids. Its peptide esters are usually cleaved by basic or nucleophilic reagents, especially by ammonia in the preparation of peptide amides.

Uses

4-(Hydroxymethyl)benzoic Acid (Eprosartan USP Related Compound E) is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent.

Uses

4-(Hydroxymethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive age nt.

Synthesis Reference(s)

Journal of the American Chemical Society, 107, p. 1365, 1985 DOI: 10.1021/ja00291a042

4-(Hydroxymethyl)benzoic acid(3006-96-0)Related Product Information

• Tris(hydroxymethyl)nitromethane
• 2-(Trifluoromethyl)benzoic acid
• p-Toluic acid
• 4-Bromomethylbenzoic acid
• 4-(Aminomethyl)benzoic acid
• o-Toluic acid
• m-Toluic acid
• 4-(Chloromethyl)benzoic acid
• 4-(Hydroxymethyl)phenoxyacetic acid
• EPROSARTAN
• Epalrestat iMpurity
• α-Methylcinnamaldehyde
• ethyl 2-((E)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetate
• (2-CHLORO-ACETYLAMINO)-ACETIC ACID METHYL ESTER
• 3-(2-THIENYL)PROPIONIC ACID
• Eprosartan related coMpound C
• 3-Thiazolidineacetic acid, 4-oxo-2-thioxo-, methyl ester
• Rhodanine-3-acetic acid