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Fmoc-L-tert-leucine

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Fmoc-L-tert-leucine Basic information

Product Name:
Fmoc-L-tert-leucine
Synonyms:
  • (S)-N-FMOC-2-AMINO-3,3-DIMETHYL BUTANOIC ACID
  • RARECHEM EM WB 0083
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-TERT-BUTYL-GLYCINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-T-LEUCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-(S)-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID
  • FMOC-L-TLE-OH
  • FMOC-L-T-BUTYLGLYCINE
  • FMOC-L-TERT-LEUCINE
CAS:
132684-60-7
MF:
C21H23NO4
MW:
353.41
Product Categories:
  • Amino Acids & Deriv.
  • CHIRAL CHEMICALS
  • API intermediates
  • Amino Acids
  • Peptide
Mol File:
132684-60-7.mol
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Fmoc-L-tert-leucine Chemical Properties

Melting point:
124-127 °C
Boiling point:
554.1±33.0 °C(Predicted)
Density 
1.209±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
≥ 35.3mg/mL in DMSO, ≥ 49.6 mg/mL in EtOH
pka
3.92±0.10(Predicted)
form 
powder to crystal
color 
White to Light yellow
BRN 
6662856
CAS DataBase Reference
132684-60-7(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29242990

MSDS

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Fmoc-L-tert-leucine Usage And Synthesis

Chemical Properties

solid

Uses

Fmoc-Tle-OH is a versatile reactant used in the discovery of potent antagonists of antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) for treatment of cancer. It is also used as reactant in the preparation of phosphino dipeptide derivatices as ligand in copper-phosphine catalyst for asymmetric conjugate addition of alkylzinc reagents to unsaturated ketones.

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