TRYPROSTATIN A Chemical Properties

Melting point:

119-120 °C

Boiling point:

666.4±55.0 °C(Predicted)

Density 

1.26±0.1 g/cm3(Predicted)

pka

12.99±0.40(Predicted)

form 

White powder.

TRYPROSTATIN A Usage And Synthesis

Uses

Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939[1].

Definition

ChEBI: Tryprostatin A is a cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at positions 2 and 6 on the indole ring by prenyl and methoxy groups respectively. It has a role as a breast cancer resistance protein inhibitor. It is a dipeptide, a member of indoles, a pyrrolopyrazine, an aromatic ether and an indole alkaloid. It is functionally related to a brevianamide F.

References

[1] CHENG-BIN CUI, et al. Tryprostatins A and B, Novel Mammalian Cell Cycle Inhibitors Produced by Aspergillus fumigatus. The Journal of Antibiotics. 1995, 48.

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