Orazamide
Orazamide Basic information
- Product Name:
- Orazamide
- Synonyms:
-
- aicamindihydrate
- aicaorotatedihydrate
- aicoratdihydrate
- imidazole-4-carboxamide,5-amino-,compd.withoroticacid(1:1),dihydrate
- 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid compound with 5-amino-1h-imidazole-4-carboxamide (1:1)
- 4-amino-5-imidazolecarboxamideorotatedihydrate
- 5-Aminoimedazole-4-carboxamideorotate
- 5-aminoimidazole-4-carboxamideorotatedihydrate
- CAS:
- 2574-78-9
- MF:
- C9H10N6O5
- MW:
- 282.21
- EINECS:
- 219-923-7
- Product Categories:
-
- API
- Mol File:
- 2574-78-9.mol
Orazamide Chemical Properties
- Melting point:
- 284-285 °C (decomp)
- InChI
- InChI=1S/C5H4N2O4.C4H6N4O.2H2O/c8-3-1-2(4(9)10)6-5(11)7-3;5-3-2(4(6)9)7-1-8-3;;/h1H,(H,9,10)(H2,6,7,8,11);1H,5H2,(H2,6,9)(H,7,8);2*1H2
- InChIKey
- RAZMBRTXTADRMQ-UHFFFAOYSA-N
- SMILES
- C1(C(=O)O)NC(NC(=O)C=1)=O.C1(C(=O)N)NC=NC=1N.O.O
- CAS DataBase Reference
- 2574-78-9(CAS DataBase Reference)
Orazamide Usage And Synthesis
Originator
Aicamine, Labaz , France ,1971
Uses
Orazamide is an AICA orotate. Orazamide can prevent anti-TB drug-induced liver damage by downregulating the protein expression of HMGB 1 and RAGE in liver tissue and inhibiting the secretion of inflammatory factors. Orazamide can be used in research on hepatitis and liver cirrhosis[1].
Manufacturing Process
14.4 grams of 4-amino-5-imidazolecarboxamide (monohydrate) and 17.4 grams of orotic acid (monohydrate) were dissolved with heating in 600 cc of water. The solution is decolorized with Norit, cooled and then filtered off. 28.8 grams of a white crystalline salt (dihydrate) is obtained with MP 284°C (decomposition).
Therapeutic Function
Hepatoprotectant
References
[1] HE L, et al. Study on the Prevention Mechanism of Anti-tuberculosis Drug-induced Liver Injury with Orazamide Based on HMGB1-RAGE Signaling Pathway[J]. China Pharmacy, 2021: 2229-2235.
Orazamide Preparation Products And Raw materials
Raw materials
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