Germacrone
Germacrone Basic information
- Product Name:
- Germacrone
- Synonyms:
-
- (E,E)-Germacra-3,7(11),9-trien-6-one
- (E,E)-3,7-Dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one
- 3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-
- 3,7-Dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one
- Germacra-3,7(11),9-trien-6-one, (E,E)-
- Germacron
- trans,trans-3,7-Dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one
- (3E,7E)-3,7-Dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one
- CAS:
- 6902-91-6
- MF:
- C15H22O
- MW:
- 218.33
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Inhibitors
- Mol File:
- 6902-91-6.mol
Germacrone Chemical Properties
- Melting point:
- 55-58 °C
- Boiling point:
- 153-157 °C(Press: 13 Torr)
- Density
- 0.9908 g/cm3
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- λmax
- 309nm(MeOH)(lit.)
- BRN
- 2047453
- Stability:
- Light Sensitive
- LogP
- 4.760 (est)
- CAS DataBase Reference
- 6902-91-6
- NIST Chemistry Reference
- 3,7-Cyclodecadien-1-one, 3,7-dimethyl-10-(1-methylethylidene)-, (e,e)-(6902-91-6)
Safety Information
- Safety Statements
- 23-24/25
- RTECS
- GU2210000
- HS Code
- 29142990
Germacrone Usage And Synthesis
Description
Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities. It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 μM. Germacrone (50-250 μM) enhances cytotoxicity and apoptosis induced by doxorubicin in doxorubicin-resistant MCF-7/adr cells. In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity. It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
Uses
Germacrone is an antiviral isolate of Geranium macrorrhizum which inhibits and prevents early stage influenza virus infection. It also inhibits the proliferation of glioma cells by promoting apoptosis.
Definition
ChEBI: (E,E)-germacrone is a germacrane sesquiterpenoid that has formula C15H22O. It is a natural product found in traditional medicinal plants of the family Zingiberaceae. The compound exhibits a range of pharmacological activities including anti-inflammatory, anticancer, antiviral, anti-androgenic, antioxidant, antimicrobial, antifungal, neuroprotective and insecticidal activities. It has a role as a volatile oil component, an antiviral agent, an insecticide, an anti-inflammatory agent, an antioxidant, an antineoplastic agent, an apoptosis inducer, an autophagy inducer, an antimicrobial agent, an androgen antagonist, a neuroprotective agent, a plant metabolite, an antifungal agent, an antitussive, an antifeedant and a hepatoprotective agent. It is a germacrane sesquiterpenoid and an olefinic compound.
Synthesis Reference(s)
Tetrahedron Letters, 24, p. 3489, 1983 DOI: 10.1016/S0040-4039(00)86020-7
Hazard
A poison by ingestion
Safety Profile
A poison by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
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