WITHANOLIDE B(P)(NEW)
WITHANOLIDE B(P)(NEW) Basic information
- Product Name:
- WITHANOLIDE B(P)(NEW)
- Synonyms:
-
- Withanolide B 56973-41-2
- WITHANOLIDE B(SH)(NEW)
- (5a,6a,7a,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone
- Lycium substance B
- Withanolide B
- WITHANOLIDE B(SH)
- (5α,6α,7α,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone
- WITHANOLIDE B(P)(NEW)
- CAS:
- 56973-41-2
- MF:
- C28H38O5
- MW:
- 454.6
- Mol File:
- 56973-41-2.mol
WITHANOLIDE B(P)(NEW) Chemical Properties
- Density
- 1.206
- storage temp.
- Store at -20°C
- solubility
- Acetonitrile: 0.1 mg/ml; Methanol: 0.5 mg/ml
- form
- Solid
- color
- White to off-white
- InChIKey
- ZTEVDTFJUUJBLP-MBMSZCMESA-N
WITHANOLIDE B(P)(NEW) Usage And Synthesis
Uses
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects[1][2][3].
Definition
ChEBI: Withanolide B is a withanolide.
in vivo
Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model[1].
| Animal Model: | Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect[1] |
| Dosage: | 10 mg/kg |
| Administration: | Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days) |
| Result: | Increased the trabecular number, trabecular thickness and the thickness of the cortical bone. |
References
[1] Kuang Z, et, al. Withanolide B promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERK1/2 and Wnt/β-catenin signaling pathways. Int Immunopharmacol. 2020 Nov;88:106960. DOI:10.1016/j.intimp.2020.106960
[2] Dubey S, et, al. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. Int J Biol Macromol. 2021 Mar 15;173:56-65. DOI:10.1016/j.ijbiomac.2021.01.094
[3] Sivanandha G, et, al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. PLoS One. 2014 Aug 4;9(8):e104005. DOI:10.1371/journal.pone.0104005
WITHANOLIDE B(P)(NEW)Supplier
- Tel
- +86-21-20908456
- sales@BioChemBest.com
- Tel
- 021-51320588
- tauto@tautobiotech.com
- Tel
- 0510-85629785 18013409632
- sales@reading-chemicals.com
- Tel
- 027-87465837 19945049750
- sales@finetechnology-ind.com
- Tel
- 18607101326 15172504745
- aileen@chemfaces.com
WITHANOLIDE B(P)(NEW)(56973-41-2)Related Product Information
- Vitamin B6
- WITHANOLIDE A(P)
- (1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone
- Withanolides
- Withanolide C
- buddlejasaponin IV
- (22R)-5β,6β-Epoxy-3-methoxy-1-oxo-4β,22,27-trihydroxyergost-24-en-26-oic acid 26,22-lactone
- (13R,22R)-13,14:18,20-Diepoxy-14,18,22-trihydroxy-1-oxo-13,14-secoergosta-2,5,24-trien-26-oic acid 26,22-lactone
- (22R)-14,20,22-Trihydroxy-1-oxoergosta-2,5,24-triene-18,26-dioic acid 18,20:26,22-dilactone
- Withaphysalin E
- Withaperuvin C
- WITHANOSIDEIV
- Withaphysalin S
- (22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione
- WILFORINE
- WILFORDINE
- WILFORGINE
- wilfortrine