3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- CAS#: 514-62-5

ChemicalBook > Product Catalog > Natural Products > Terpenes > 3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-

Basic information Safety Supplier Related

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- Basic information

Product Name:

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-

Synonyms:

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-
(+)-8,11,13-Abietatrien-12-ol
(4aS)-1,1,4aβ-Trimethyl-7-isopropyl-1,2,3,4,4a,9,10,10aα-octahydrophenanthrene-6-ol
(4bS)-4b,5,6,7,8,8aβ,9,10-Octahydro-4b,8,8-trimethyl-2-isopropylphenanthren-3-ol
8,11,13-Abietatriene-12-ol
abieta-8,11,13-triene-12-ol

CAS:

514-62-5

MF:

C20H30O

MW:

286.45

Mol File:

514-62-5.mol

Less

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- Chemical Properties

Melting point:: 56-57℃
Boiling point:: 388.1±31.0 °C(Predicted)
Density: 0.988±0.06 g/cm3 (20 ºC 760 Torr)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 10.89±0.60(Predicted)
color: White to off-white
optical activity: +40.616 (c4, ethanol)
InChI: InChI=1S/C20H30O/c1-13(2)15-11-14-7-8-18-19(3,4)9-6-10-20(18,5)16(14)12-17(15)21/h11-13,18,21H,6-10H2,1-5H3/t18-,20+/m0/s1
InChIKey: QXNWVJOHUAQHLM-AZUAARDMSA-N
SMILES: C1=C2C([C@]3(C)[C@@]([H])(CC2)C(C)(C)CCC3)=CC(O)=C1C(C)C

Less

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)- Usage And Synthesis

Uses

Ferruginol can be used for its antibacterial activities.

Definition

ChEBI: Ferruginol is an abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12. It has a role as an antineoplastic agent, an antibacterial agent, a protective agent and a plant metabolite. It is an abietane diterpenoid, a member of phenols, a carbotricyclic compound and a meroterpenoid.

in vivo

Ferruginol (20 mg/kg; p.o.; daily; for 4 weeks) exerts cardioprotection manifested as enhanced cardiac function and reduced structural damage and apoptosis. The transcriptome and other results revealed that Ferruginol facilitates PGC-1α-mediated mitochondrial biogenesis and fatty acid oxidation (MB and FAO) by increasing the expression of PGC-1α and concurrently promoting the expression of SIRT1-enhancing deacetylase SIRT1 deacetylating and activating PGC-1α^[3].

Animal Model:	Male C57BL/6 mice (20 g, 8-10 weeks old) with Doxorubicin (DOX)-induced cardiotoxicity (DIC)^[3].
Dosage:	20 mg/kg
Administration:	Administered intragastrically; daily; for 4 weeks
Result:	Relieved Doxorubicin-induced cardiac structural and functional lesion.

target

PARP | Bcl-2/Bax | Caspase | Antifection

3-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS,8aS)-Supplier

BioBioPha Co., Ltd. Gold

Tel: 0871-65217109 13211707573;
Email: y.liu@mail.biobiopha.com

Sichuan BioCrick Biotech Co., Ltd Gold

Tel: 28-86-28-8543-3893 13260669172
Email: sales@biocrick.com

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Email: 3003855609@qq.com

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Email: sales@reading-chemicals.com

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Email: sales@jhechem.com

Less