esperamicin A1 Chemical Properties

Density 

1.43±0.1 g/cm3(Predicted)

pka

6.67±0.70(Predicted)

CAS DataBase Reference

99674-26-7

esperamicin A1 Usage And Synthesis

Uses

Esperamicin A1, as an extremely potent antitumor antibiotic, is isolated from cultures of Actinomadura verrucosospora. Esperamicin A1 can be used for the research of antitumor[1]. Eesperamicin A1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Definition

ChEBI: A naturally occurring antibiotic and antitumor agent isolated from Actinomadura verrucosopora. Its chemical structure consists of a core bicyclo[7.3.1]tridecadiynene moiety containing a 1,5-diyn-3-ene as part of a ten-membered ring, a lpha,beta-unsaturated ketone with a bridgehead double bond and an attached allylic trisulfide. This ring system is attached at one end by a trisaccharide moiety and at the opposite end by a 2-deoxy-L-fucose-anthra ilate moiety. The trisaccharide consists of a hydroxyamino sugar which is connected to a isopropylamino sugar through a glycosidic linkage and a thiomethyl sugar through an NH1O linkage.

References

[1] Lam, K. S., et al. Biosynthesis of esperamicin A1, an enediyne antitumor antibiotic. Journal of the American Chemical Society, 115(26), 12340–12345.

esperamicin A1(99674-26-7)Related Product Information

• 5-HEXYN-3-OL
• ACETALDEHYDE ETHYL CIS-3-HEXENYL ACETAL
• ISOPROPYL ANTHRANILATE
• TETRAHYDRO-2-(2-PROPYNYLOXY)-2H-PYRAN
• 3-Prop-2-ynoxypropane-1,2-diol
• Ethynyl methyl vinyl carbinol
• 6-Heptyn-1-ol
• 2,3,4-TRITHIAHEXANE
• Methyl 2-amino-4,5-dimethoxybenzoate
• O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
• Methyl allyl trisulfide
• 1-FORMAMIDO-1-CYCLOHEXENE
• 3-PENTYN-1-OL
• 2-Amino-4,5-dimethoxybenzoic acid
• Dimethyl trisulfide
• 1,7-OCTADIYNE
• ETHYL 2-AMINO-5-METHOXYBENZOATE
• 1-HEPTEN-6-YNE