GENTISEIN Chemical Properties

storage temp. 

-20°C

solubility 

DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml,Ethanol: 20 mg/ml

form 

A solid

color 

Light yellow to yellow

GENTISEIN Usage And Synthesis

Uses

Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 μM[1][2].

Definition

ChEBI: A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3 and 7.

References

[1] Wang H, et al. Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed Anal. 2007;45(5):793-798. DOI:10.1016/j.jpba.2007.07.019
[2] Tzankova, Virginia et al. (2010). Inhibition of 5-HT uptake by some constituents of Hypericum annulatum in rat brain in vitro. Pharmacologyonline. 2.

GENTISEIN(529-49-7)Related Product Information

• Gamma-mangostin
• GENTISIN
• isomangiferin
• 1-Isomangostin
• Mangiferin
• Mangostin
• Neomangiferin
• 3-isomangostin
• Beta-mangostin
• GENTISEIN
• isogentisin
• 9H-Xanthen-9-one, 1,3,7-trimethoxy-
• 1-HYDROXY-3,7-DIMETHOXYXANTHONE
• HYDROXYCALABAXANTHONE, 9-
• SWERTIANIN (SWERTIAE)
• 5-18-05-00186 (Beilstein Handbook Reference)
• manglexanthone