Methyl 3-aminocrotonate
Methyl 3-aminocrotonate Basic information
- Product Name:
- Methyl 3-aminocrotonate
- Synonyms:
-
- METHYL-BETA-AMINOCROTONATE
- METHYL 4-AMINOCROTONATE
- METHYL 3-AMINOCROTONATE
- METHYL 3-AMINO-2-BUTENOATE
- AMINOCROTONIC ACID METHYL ESTER
- 3-AMINOCROTONATE METHYL ESTER
- 3-AMINOCROTONIC ACID METHYL ESTER
- 3-AMINO-2-BUTENOIC ACID METHYL ESTER
- CAS:
- 14205-39-1
- MF:
- C5H9NO2
- MW:
- 115.13
- EINECS:
- 238-056-5
- Product Categories:
-
- Aliphatics
- Amines
- API intermediates
- 14205-39-1
- Mol File:
- 14205-39-1.mol
Methyl 3-aminocrotonate Chemical Properties
- Melting point:
- 81-83 °C(lit.)
- Boiling point:
- 112°C 42mm
- Density
- 1.1808 (rough estimate)
- vapor pressure
- 2.79-2.853hPa at 25℃
- refractive index
- 1.4538 (estimate)
- Flash point:
- 91 °C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- 18g/l
- form
- Crystalline Powder
- pka
- 5.27±0.70(Predicted)
- color
- White to slightly yellow
- PH
- 8-9 (18g/l, H2O, 20℃)
- Water Solubility
- insoluble
- Sensitive
- Hygroscopic
- BRN
- 956592
- InChIKey
- XKORCTIIRYKLLG-ONEGZZNKSA-N
- LogP
- -0.27 at 25℃
- CAS DataBase Reference
- 14205-39-1(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Butenoic acid, 3-amino-, methyl ester (14205-39-1)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 37/39-26-24/25
- WGK Germany
- 3
- RTECS
- EM9092500
- TSCA
- Yes
- HS Code
- 29224995
MSDS
- Language:English Provider:Methyl 3-aminocrotonate
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
Methyl 3-aminocrotonate Usage And Synthesis
Chemical Properties
Crystals, yellowish-white
Uses
Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet
Uses
Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity.
Uses
Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified.
Preparation
3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.
General Description
Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.
Flammability and Explosibility
Not classified
Methyl 3-aminocrotonate Preparation Products And Raw materials
Preparation Products
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