Neocryptotanshinone
Neocryptotanshinone Basic information
- Product Name:
- Neocryptotanshinone
- Synonyms:
-
- Neocryptotanshinone
- 5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione
- 1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-
- (R)-3-Hydroxy-2-(1-hydroxypropan-2-yl)-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-1,4-dione
- CAS:
- 109664-02-0
- MF:
- C19H22O4
- MW:
- 314.38
- Mol File:
- 109664-02-0.mol
Neocryptotanshinone Chemical Properties
- Boiling point:
- 517.1±50.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 4.50±1.00(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C19H22O4/c1-10(9-20)14-16(21)12-6-7-13-11(5-4-8-19(13,2)3)15(12)18(23)17(14)22/h6-7,10,20,22H,4-5,8-9H2,1-3H3/t10-/m0/s1
- InChIKey
- PKEGICXVZMKJPR-JTQLQIEISA-N
- SMILES
- C1(=O)C2=C(C3=C(C=C2)C(C)(C)CCC3)C(=O)C(O)=C1[C@@H](C)CO
Neocryptotanshinone Usage And Synthesis
Uses
Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].
in vivo
Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)[3].
| Animal Model: | MSU-induced pain model in male ICR mice (weighing 20-25 g)[2] |
| Dosage: | 10, 25, 50 or 100 mg/kg |
| Administration: | Oral gavage; for 30, 60, 120 min |
| Result: | Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner. |
IC 50
iNOS
References
[1] Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9. DOI:10.1016/j.apsb.2015.01.010
[2] H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50. DOI:10.1021/np000345v
[3] FENG Jinghui, et al. Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro. J Tradit Chin Med. 2021. 41(2): 219-226. PMID:33825401
NeocryptotanshinoneSupplier
- Tel
- 13348960310
- 3003867561@qq.com
- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
- Tel
- 021-51320588
- tauto@tautobiotech.com
- Tel
- 0510-85629785 18013409632
- sales@reading-chemicals.com
- Tel
- 15221275939
- shenlinxing@macklin.cn
Neocryptotanshinone(109664-02-0)Related Product Information
- Tanshinone IIA
- Salvianolic acid
- Salvianolicacid C
- 3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid
- magnessium lithospermate B
- 9'''-MethyllithosperMate B
- 9'''-MethyllithosperMate B
- Sodium danshensu
- TanshinoneIIA
- 7-Ethyl-10-hydroxycamptothecin
- 5,6,7,8-Tetrahydro-3-hydroxy-2-isopropyl-8,8-dimethyl-1,4-phenanthrenedione
- 1,2-Didehydrocryptotanshinone
- (8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
- TANSHINONE ⅡA
- Cryptotanshinone