S-acetyl-PEG8 alcohol Usage And Synthesis

Description

S-acetyl-PEG8-alcohol is a PEG linker containing a sulfur acetyl group and an alcohol group. The sulfur acetyl can be deprotected to generate thiol groups. The alcohol group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. Longer PEG chains enhance the water solubility properties of compound compared to shorter PEG chains.

Uses

S-Acetyl-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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