S-acetyl-PEG3-t-butyl ester CAS#: 1818294-27-7

S-acetyl-PEG3-t-butyl ester Basic information

Product Name:

S-acetyl-PEG3-t-butyl ester

Synonyms:

S-acetyl-PEG3-t-butyl ester
S-acetyl-PEG3-Boc
4,7,10-Trioxa-13-thiapentadecanoic acid, 14-oxo-, 1,1-dimethylethyl ester
tert-butyl 2-oxo-6,9,12-trioxa-3-thiapentadecan-15-oate
tert-butyl 3-((2-(2-(acetylthio)ethoxy)ethoxy)ethoxy)propanoate
AcS-PEG3-COOtBu

CAS:

1818294-27-7

MF:

C15H28O6S

MW:

336.44

Mol File:

1818294-27-7.mol

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S-acetyl-PEG3-t-butyl ester Chemical Properties

Boiling point:: 413.9±35.0 °C(Predicted)
Density: 1.085±0.06 g/cm3(Predicted)

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S-acetyl-PEG3-t-butyl ester Usage And Synthesis

Description

S-acetyl-PEG3-t-butyl ester is a PEG linker containing a sulfur acetyl group and a t-butyl ester. The sulfur acetyl group can be deprotected to form a thiol group. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Uses

S-acetyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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