S-Acetyl-PEG3-Azido Chemical Properties

form 

clear liquid

color 

Light yellow to Brown

Safety Information

HS Code 

2929.90.5090

S-Acetyl-PEG3-Azido Usage And Synthesis

Description

S-Acetyl-PEG3-azide is a PEG linker containing an azide group and a sulfur acetyl group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

S-Acetyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. S-Acetyl-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

S-Acetyl-PEG3-Azido(1310827-26-9)Related Product Information

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• S-acetyl-PEG6-t-butyl ester
• S-acetyl-PEG4-t-butyl ester
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• S-acetyl-PEG3-t-butyl ester
• S-acetyl-PEG3-phosphonic acid ethyl ester
• S-acetyl-PEG2-t-butyl ester
• S-acetyl-PEG3-alcohol
• S-acetyl-PEG3-acid