S-acetyl-PEG6-t-butyl ester CAS#: 1818294-39-1

S-acetyl-PEG6-t-butyl ester Basic information

Product Name:

S-acetyl-PEG6-t-butyl ester

Synonyms:

S-acetyl-PEG6-t-butyl ester
S-acetyl-PEG6-Boc
tert-butyl 2-oxo-6,9,12,15,18,21-hexaoxa-3-thiatetracosan-24-oate
4,7,10,13,16,19-Hexaoxa-22-thiatetracosanoic acid, 23-oxo-, 1,1-dimethylethyl ester

CAS:

1818294-39-1

MF:

C21H40O9S

MW:

468.6

Mol File:

1818294-39-1.mol

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S-acetyl-PEG6-t-butyl ester Chemical Properties

Boiling point:: 522.5±50.0 °C(Predicted)
Density: 1.094±0.06 g/cm3(Predicted)

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S-acetyl-PEG6-t-butyl ester Usage And Synthesis

Description

S-acetyl-PEG6-t-butyl ester is a PEG linker containing a sulfur acetyl group and a t-butyl ester. The sulfur acetyl group can be deprotected to form a thiol group. The t-butyl ester can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Uses

S-acetyl-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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