3,5-Bis(trifluoromethyl)phenol Chemical Properties

Melting point:

20-21 °C(lit.)

Boiling point:

97 °C50 mm Hg(lit.)

Density 

1.511 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.415(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

7.96±0.10(Predicted)

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Specific Gravity

1.511

BRN 

2123670

CAS DataBase Reference

349-58-6(CAS DataBase Reference)

NIST Chemistry Reference

3,5-Xylenol, aplha,aplha,aplha,aplha',aplha',aplha'-hexafluoro-(349-58-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29081990

MSDS

• Language:English Provider:3,5-Di(trifluoromethyl)phenol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3,5-Bis(trifluoromethyl)phenol Usage And Synthesis

Chemical Properties

CLEAR SLIGHTLY BROWN LIQUID

Uses

3,5-Bis(trifluoromethyl)phenol (BTMP) has been used as hydrogen donor in synergistic extraction of aluminium (III) and gallium (III) with 2,4-pentanedione in heptane.

Synthesis

General procedure for the synthesis of 3,5-bis(trifluoromethyl)iodobenzene from 3,5-bis(trifluoromethyl)iodobenzene: In a test tube equipped with a magnetic stirrer, 3,5-bis(trifluoromethyl)iodobenzene (1.0 mmol), CuCl2 (13.4 mg, 0.1 mmol), KOH (336 mg, 6.0 mmol), ethylene glycol (12 μL, 0.2 mmol), and DMSO/H2O mixed solvent (1.0 mL/0.5 mL). The system was replaced by argon gas and then placed in an oil bath preheated to 120 °C with stirring for 24 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted by partitioning with 5% HCl aqueous solution and ethyl acetate. The organic phase was washed sequentially with water and saturated saline, dried over anhydrous MgSO4 and concentrated under reduced pressure to remove the solvent. The crude product was further purified by column chromatography (eluent: EtOAc/hexane) to afford the target product 3,5-bis(trifluoromethyl)phenol.

References

[1] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 12, p. 2833 - 2840

3,5-Bis(trifluoromethyl)phenol(349-58-6)Related Product Information

• m-Cresol
• Cresol
• 3-(Trifluoromethyl)benzaldehyde
• Bisphenol A
• 3,5-Dimethylphenol
• Phenol Red
• 4-Fluorophenol
• 2,5-Dimethylphenol
• 2-(Trifluoromethyl)benzoic acid
• Xylenol
• o-Cresol
• Phenol
• 3-Aminobenzotrifluoride
• Benzotrifluoride
• p-Cresol
• 2,6-Dimethylphenol
• Nonylphenol
• Trifluoromethanesulfonic acid