Glabrone Chemical Properties

Boiling point:

554.1±50.0 °C(Predicted)

Density 

1.368±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

6.91±0.20(Predicted)

form 

Solid

color 

Light yellow to yellow

InChI

InChI=1S/C20H16O5/c1-20(2)8-7-14-16(25-20)6-5-12(18(14)22)15-10-24-17-9-11(21)3-4-13(17)19(15)23/h3-10,21-22H,1-2H3

InChIKey

COLMVFWKLOZOOP-UHFFFAOYSA-N

SMILES

C1OC2=CC(O)=CC=C2C(=O)C=1C1C(O)=C2C(=CC=1)OC(C)(C)C=C2

Glabrone Usage And Synthesis

Uses

Glabrone is an isoflavone isolated from Glycyrrhiza glabra roots. Glabrone exhibits anti-influenza activity and significant PPAR-γ ligand-binding activity[1][2].

Definition

ChEBI: Glabrone is an isoflavonoid.

IC 50

PPAR-γ

References

[1] Grienke U, et al. Computer-guided approach to access the anti-influenza activity of licorice constituents. J Nat Prod. 2014 Mar 28;77(3):563-70. DOI:10.1021/np400817j
[2] Kuroda M, et al. Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity. Bioorg Med Chem. 2010 Jan 15;18(2):962-70. DOI:10.1016/j.bmc.2009.11.027

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