1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione Chemical Properties

Melting point:

244.5-246.0 °C

Boiling point:

614.9±55.0 °C(Predicted)

Density 

1.409±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO

form 

Solid

pka

6.16±0.20(Predicted)

color 

Yellow to orange

1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione Usage And Synthesis

Uses

Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1].

Definition

ChEBI: Obtusin is a dihydroxyanthraquinone.

References

[1] Paudel P, et al. In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds. ACS Omega. 2019 Sep 18;4(14):16139-16152. DOI:10.1021/acsomega.9b02328

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