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Polyphyllin VI

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Polyphyllin VI Basic information

Product Name:
Polyphyllin VI
Synonyms:
  • Polyhyllin VI
  • (2R,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((2'R,4S,5'R,6aR,6bS,8aS,8bS,9S,11aS,12
  • Polyphyllin VI
  • Polyphyllin Ⅵ
  • Polyphyllin F (Polyphyllin VI)
  • Chonglou saponin Ⅵ
  • 17-Hydroxyparis V
  • Paris saponin VI
CAS:
55916-51-3
MF:
C39H62O13
MW:
738.9
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
55916-51-3.mol
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Polyphyllin VI Chemical Properties

Melting point:
216-220°C
Boiling point:
871.2±65.0 °C(Predicted)
Density 
1.38
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
12.85±0.70(Predicted)
color 
White to Off-White
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Polyphyllin VI Usage And Synthesis

Uses

Polyhyllin VI is a natural saponin extracted from the plant, Rhizoma Paridis, and displays anti-proliferative activity in vivo. Used in the treatment of HepG2 cells for tumor mitigation.

in vivo

Polyphyllin VI (2-4 mg/kg; i.p.; five times a week for 4 weeks) inhibits the growth of lung cancer tumor xenografts[1].
Polyphyllin VI (2.5-10 mg/kg; i.p.; 10 consecutive days) activates NLRP3 inflammasome in A549-bearing athymic nude mice[3].

Animal Model:A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[1]
Dosage:2 mg/kg, 3 mg/kg, 4 mg/kg
Administration:Intraperitoneal Injection (i.p.)
Result:Resulted the reduction of tumor volume to 25.63%, 41.71%, and 40.41%, respectively, after 2 mg/kg, 3 mg/kg and 4 mg/kg treatment.
Animal Model:A549 tumor xenografts subcutaneously inoculated into the right flank of the nude mice[3]
Dosage:2.5 mg/kg, 5 mg/kg, 10 mg/kg
Administration:Intraperitoneal Injection (i.p.)
Result:Showed the expression of NLRP3, caspase-1, IL-1β and GSDMD was increasing in a dose manner.

Polyphyllin VISupplier

Chengdu Gupte Biotechnology Co., Ltd. Gold
Tel
13881890404
Email
2851503757@qq.com
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Email
cdhxsj@163.com
Aktin Chemicals, Inc.
Tel
86-28-85159085
Email
info@aktinchem.com
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Email
sales@sungening.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
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